Longevity
Metformin's AMPK-mTOR Axis May Redefine Clinical Approaches to Biological Aging
A diabetes drug taken by hundreds of millions of people worldwide may be quietly doing something far more profound…
Studies
Corticosteroid Knee Injections Offer Short Relief But Risk Cartilage Damage Long-Term
For the millions of adults managing knee osteoarthritis, intra-articular corticosteroid injections have become a go-to…
Longevity
Cancer-Like Mutations in Brain Immune Cells May Fuel Alzheimer's Neuroinflammation
The boundary between cancer biology and neurodegeneration research is proving far more porous than previously assumed…
Studies
NEJM Reviews Myeloproliferative Neoplasm Biology, Diagnosis, and Emerging Therapies
Blood cancers driven by clonal stem cell mutations occupy a unique space in oncology — they evolve slowly, often over…
Studies
Endometriosis Linked to Elevated Psychiatric Burden Up to a Decade Before Formal Diagnosis
For the millions of women living with endometriosis, the condition's invisible toll extends far beyond pelvic pain…
Studies
Serum Protein Panel Tracks Duchenne Muscular Dystrophy Progression Across Multi-Year Trial
For a disease that robs boys of mobility before adolescence, having a reliable blood-based readout of disease…
Studies
AI Matches Human Accuracy in Pain Score Extraction From Clinical Notes
Accurate extraction of patient-reported outcomes from clinical records is a bottleneck that quietly shapes the quality…
PREPRINTStudies
Atorvastatin Linked to 2.2x Hemorrhagic Stroke Risk in Post-Infarction Medicare Patients
Among 70,130 Medicare beneficiaries aged 65+ hospitalized for myocardial or cerebral infarction, initiating…
PREPRINTStudies
871-Person Asian Cohort Finds Gut Microbiome Poorly Predicts Obesity
Shotgun metagenomic analysis of 871 ethnically diverse Singaporean adults (Chinese, Malay, and Indian participants)…
PREPRINTStudies
Ebola Data Showed 8-Fold CFR Uncertainty: Why Outbreak Analytics Need Estimand-First Design
Using longitudinal surveillance records from the 2018–2020 eastern DRC Ebola outbreak and archived forecasts from…
PREPRINTStudies
4 Drug Classes Associated with Shifts in 7 CRC-Linked Gut Bacteria in 1,034-Person Cohort
Among 83 prescription drugs tested in 1,034 colonoscopy-referred adults aged 55–77, 38 altered gut microbial diversity…
PREPRINTStudies
Air Pollution and Poverty Explain Much of Ethnic T2D Complication Gap in 175K Dutch Cohort
Among 175,112 Dutch adults with type 2 diabetes followed in the DIAMANT primary care cohort, striking ethnic…
Fitness
Protein + Resistance Training Beats Synbiotics for T2DM Muscle Strength in Men Over 65
In a triple-blinded RCT, 51 men aged ≥65 with type 2 diabetes were randomized to resistance training plus either a…
Studies
Newly Identified MACIR Protein Regulates RAD51 Removal During DNA Break Repair
Every time a cell's DNA suffers a double-strand break — one of the most catastrophic forms of genetic damage — it must…
Studies
Tonsil Organoid Model Reveals EBV Hijacks Germinal Center B Cells During Initial Infection
Nearly every adult on Earth carries Epstein–Barr virus silently in their memory B cells — a latency that occasionally…
Studies
CRISPR Model Reveals Myeloid Cell Dependency Differences in Deadly Pediatric Brain Tumors
Diffuse midline glioma remains one of the most devastating brain cancers in children, with median survival under 15…
Studies
New Statistical Tool Establishes Causal Gene Regulation From CRISPR Screen Data
Most genomic research can tell us which genes move together — but not which ones actually drive the others. That…
Studies
Hidden Binding Pockets in ARID1B Unlock New Cancer Drug Target Strategy
Nearly one in ten human cancers carries a mutation that disables ARID1A, a chromatin-remodeling protein critical for…
Longevity
MicroRNA-34a Drives Wet AMD Blindness Via Dual Angiogenic Pathway
Wet age-related macular degeneration remains one of the most treatment-resistant causes of blindness in older adults…
Studies
Host Protein TBC1D23 Found Essential for AAV Gene Therapy Vector Trafficking
Gene therapy's clinical promise depends on a deceptively simple premise: that a viral vector can reliably navigate the…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.