Longevity
Meta-Analysis Tests 16 Epigenetic Clocks Against 51 Longevity Interventions
The promise of epigenetic clocks has always been tantalizing: a molecular readout of how fast you're actually aging…
Studies
FOBT Colorectal Screening Cuts CRC Mortality More Than Raw Data Suggest
Colorectal cancer screening statistics routinely understate the true benefit of fecal occult blood testing — a…
Wellbeing
Largest Human Hippocampal Atlas Links Disrupted Neurogenesis to Depression Mechanisms
Depression research has long been hampered by a fundamental gap: the molecular machinery inside the living human…
Longevity
Deep Learning Reveals Nuclear Enlargement as Quantifiable Skeletal Muscle Aging Marker
Identifying reliable tissue-level markers of biological aging has long been a bottleneck for both clinical assessment…
Longevity
DNA Methylation Clocks Fail Key Surrogate Endpoint Validation Tests
For anyone banking on epigenetic clocks to guide longevity interventions, this investigation lands as a serious…
Wellbeing
NHS Psilocybin Trial Shows Feasibility for Treatment-Resistant Depression
For the millions living with depression that fails to respond to conventional antidepressants, the question is no…
Studies
Phase 3 Trial: Perioperative Apalutamide Cuts Prostate Cancer Residual Disease Tenfold
For the roughly half of high-risk localized prostate cancer patients who relapse within five years of surgery…
PREPRINTStudies
New Mortality Algorithm NeMMo Outperforms EuroMOMO in Detecting Pandemic Death Spikes
Analyzing weekly all-cause mortality data from 31 European countries (2015 onward, COVID-19 period excluded from…
PREPRINTStudies
Four MDR-TB Strains Drive 46% of Argentina's New Cases Over Decade
Genotyping of 1,189 multidrug-resistant Mycobacterium tuberculosis isolates collected across Argentina from 2013–2022…
PREPRINTLongevity
DunedinPACE Age Norms Derived from 37,855 Individuals Across 11 Cohorts
A meta-analysis of 11 cohorts encompassing 37,855 individuals aged 17–99 established the first population-based age…
PREPRINTStudies
1-in-3 Indian Children Have NAFLD; Obese Youth Hit 60% Prevalence
Pooling data from 11 Indian studies covering 3,512 children and adolescents under 18, this meta-analysis estimates an…
PREPRINTLongevity
Community-Level Urbanization and Wealth Concentration Linked to Higher Hypertension Odds Among Overweight Ethiopian Adults
Among 3,842 overweight and obese Ethiopian adults drawn from 612 clusters in the nationally representative 2024–25…
Supplements
GLP-1 Drugs Linked to 57% Lower Papilledema Risk in Intracranial Hypertension Patients
Across eight studies enrolling 13,243 patients, GLP-1 receptor agonists (GLP-1 RAs) produced striking reductions in…
Longevity
Evolved Gut Bacteria Extend Lifespan via Acetate in Drosophila Model
Applying directed evolution to the Drosophila gut microbiome outside the host generated a paraquat-resistant (PQR)…
Longevity
17α-Estradiol Cuts Fat in APOE4 Females But Misses Brain Targets
Treating 12-month-old female mice carrying the APOE4 Alzheimer's risk allele with 14.4ppm 17α-estradiol (17αE2) for…
Studies
New 10-Item Social Frailty Tool Shows Strong Psychometric Properties in Older Adults
Social isolation and disconnection accelerate physical decline in aging populations, yet clinicians have lacked a…
Studies
Off-the-Shelf KRAS Vaccine Triggers Durable T-Cell Response in High-Risk Adults
Pancreatic cancer remains one of medicine's most intractable challenges precisely because it is almost never caught…
Studies
School-Level Measles Data Revealed Epidemic Risk Hidden by County Averages
When public health surveillance operates at the wrong geographic scale, it can miss a crisis building in plain sight…
Longevity
CDK6 Inhibition Silences Senescent Cell Inflammation, Reversing Age-Related Decline in Mice
The chronic low-grade inflammation produced by senescent cells — the so-called senescence-associated secretory…
Longevity
ANGPTL8 Protein Drives Fat Tissue Aging Via AKT2-mTOR Signaling Cascade
For decades, adipose tissue was dismissed as passive energy storage, but mounting evidence positions it as a master…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.