PREPRINTLongevity
52 Blood Proteins Link Exercise to Pre-Cancer Signatures 7+ Years Early
Across 674 serum samples from the Singapore Longitudinal Ageing Studies (n=6,050), proteomics profiling of over 2,400…
Fitness
45-Min Daily Treadmill Reverses Diabetic Hippocampal Damage via KLOTHO and NZF-2b
Four weeks of 45-minute daily treadmill exercise significantly reversed diabetes-induced hippocampal deterioration in…
Fitness
12-Week Exercise Trial Targets 52% Post-Stroke Cognitive Decline in 6-Month Window
Post-stroke cognitive impairment afflicts up to 52% of survivors within 6 months, and 20% progress to clinical…
Studies
Foodborne Pathogens Caused 666 Million Illnesses Globally in 2021
Understanding exactly which pathogens are driving preventable deaths from contaminated food — and where — has major…
Studies
Mouse Study Links von Willebrand Factor Activation to No-Reflow After Stroke Reperfusion
Restoring blood flow after a stroke sounds like the obvious solution — and it is the cornerstone of emergency…
Studies
Cortical Myelin Saves Energy in Brain Signaling Without Boosting Speed
A foundational assumption about brain wiring — that myelin's primary job is to make signals travel faster — may need…
Studies
Brain Circuit Linking Parabrachial Neurons to Hypothalamus Controls Both Hunger and Anxiety
A fundamental assumption in neuroscience has long been that hunger regulation and anxiety are governed by largely…
Longevity
Dual Proteasome Inhibitors Form Redundant Cellular Protein-Clearance Safeguard
Precise control over how cells destroy their own proteins sits at the heart of aging, neurodegeneration, and cancer…
Studies
Lipid Kinase Rivalry: PIP4K Disrupts PIP5K Dimerization to Curb PI(4,5)P2 Levels
Cellular membranes are far more than passive barriers — they serve as dynamic signaling platforms whose lipid…
Studies
Peroxisomal Ether Lipids Found to Govern Brain Cortex Development via Mitochondrial Crosstalk
How the brain constructs its most complex structure — the cerebral cortex — hinges on molecular decisions made inside…
Studies
Single-Molecule Imaging Reveals How Protein Aggregation Inhibitors Intercept Early Oligomers
Understanding exactly when and how protein clumping goes wrong matters enormously for diseases like Alzheimer's…
Studies
Cancer-Driving G-Protein Signals Require Endolysosomal Trafficking for Full Oncogenic Activity
For decades, the textbook model of G-protein-coupled receptor (GPCR) signaling placed all meaningful activity at the…
Studies
Structural Loop Rigidity Explains How Calcium Channel Beta Subunits Control Neuronal Signaling
Calcium channel regulation sits at the heart of pain signaling, neurotransmitter release, and synaptic plasticity…
Wellbeing
Skin-Worn Liquid Metal Patch Delivers Vagus Nerve Stimulation in Mouse Model of Depression Without Surgery
Depression affects roughly 280 million people globally, and a substantial minority — perhaps a third — do not respond…
Studies
Gephyrin Anchors PX-RICS Isoform at Inhibitory Synapses, Regulating GABAergic Balance
Maintaining the precise balance between excitatory and inhibitory signaling in the brain is fundamental to…
Studies
Hydrogen Sulfide Persulfidation Reshapes Metabolic Pathways in Salt-Stressed Rice
Salt stress is one of agriculture's most devastating crop threats, and understanding the molecular machinery that…
Studies
Lactate-Modified HSP90α Protein Unlocks Mitochondrial Growth in Ovarian Cells
Mitochondrial health is increasingly recognized as a cornerstone of reproductive biology, yet the molecular switches…
Studies
AI Models Decode KCNQ1 Variants to Predict Cardiac Arrhythmia Risk
For the millions of people carrying uncharacterized genetic variants linked to heart rhythm disorders, the gap between…
Studies
ZNF263 Protein Silences Immune Alarm System in Prostate Cancer Cells
One of the central frustrations in prostate cancer immunotherapy is that tumors simply don't look "foreign" enough to…
Longevity
New 'Senotype' Framework Classifies Aging Cells by Origin and Function
The field of cellular senescence has long wrestled with a fundamental problem: not all senescent cells are equal, yet…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.