Longevity
Caffeine Mimics Caloric Restriction via Lysosomal Fat-Burning Pathway in Worms
The idea that your morning coffee might do more than sharpen focus has gained a molecular foothold. Understanding…
Studies
Random Forest Model Predicts Liver Cancer Risk from Routine Clinical Data
Liver cancer remains one of the most lethal malignancies precisely because it is so rarely caught early. If a standard…
Nutrition
Engineered Texture-Modified Foods Show Promise for Safer Swallowing in Aging Adults
Swallowing dysfunction affects an estimated 8–16% of older adults and is among the most underappreciated drivers of…
Longevity
Combined Training + Probiotics Slash Fusobacterium, Restore mTOR Signaling in Aged Rats
In aged male Wistar rats, eight weeks of moderate-intensity resistance training combined with a multi-nutrient stack…
Longevity
Exercise-Induced Liver Hormone FGF21 Clears Brain Inflammation via AMPK-TFEB Mitophagy
Sixteen weeks of treadmill exercise in aged male C57BL/6J mice improved hippocampal cognition and reduced…
Longevity
Resveratrol Suppresses MPO in Osteoarthritic Joints via NETs Pathway
Bioinformatics analysis of GEO datasets identified 808 differentially expressed genes in osteoarthritis (OA), with…
Longevity
Review: AI Potential for Food-Derived Peptides Modulating Nrf2, mTOR, IIS Pathways and Microbiota in Longevity Models
Food-derived bioactive peptides from plant, animal, and marine sources can extend healthspan and lifespan in model…
Longevity
U-Shaped Mortality Risk: ≤8-Hour Eating Windows May Accelerate Biological Aging
Eating window duration follows a U-shaped mortality curve — a counterintuitive finding that challenges the blanket…
Studies
Fatty Acid Enzyme ACSS2 Shields EGFR From Degradation, Fueling Liver Cancer Drug Resistance
Acquired resistance to first-line therapies remains one of the most stubborn barriers in advanced liver cancer…
Studies
Next-Generation Intratumoral Agents Show Durable Responses in Checkpoint-Resistant Melanoma
For patients with advanced melanoma who have exhausted standard immune checkpoint inhibitor options, the prospect of…
Studies
First ACCP Evidence-Based Guidelines Standardize Adult Bronchiectasis Management
For millions of adults living with a condition that quietly erodes lung function year by year, clinical care has long…
Studies
Long COVID Eye Damage Tied to Neuroinflammation, Detectable Years Later
Vision problems are among the least-discussed consequences of long COVID, yet for affected individuals they can be…
Studies
31-Expert Consensus Framework Grades Oral Health Decline Risk in Older Adults
Oral health in older adults is far more dynamic than a single dental exam can reveal — and a new internationally…
Supplements
Prebiotics Raise SCFAs 31% and Cut Hepcidin 61% in Celiac Patients
For the roughly one-third of celiac disease patients who remain symptomatic despite strict gluten-free dieting…
Studies
Phase 3 Trial: Mirtazapine Reduces Methamphetamine Use Days in Australian Cohort
With no approved pharmacotherapy for methamphetamine use disorder anywhere in the world, every credible clinical trial…
Studies
PRISM2 AI Matches Clinical Cancer Detection Across Pathology Without Task-Specific Training
The prospect of a single AI system capable of reading pathology slides and answering clinical questions at…
Studies
Single Soccer Match Headers Linked to Spikes in Two Neural Damage Markers in Blood
For the millions of recreational soccer players who consider the sport a cornerstone of their fitness routine, new…
Studies
Teleoperated Humanoid Robot Completes Pig Gallbladder Surgery With Clinical Implications
The boundary between science fiction and operating-room reality is narrowing faster than most clinicians anticipated…
Studies
Global TB Burden Mapped Across 204 Nations: MDR-TB Progress Stalls
Tuberculosis remains one of the most consequential infectious disease challenges of our era, and this sweeping…
Studies
5.24 Million Clinical Scans Train Neuroimaging AI Outperforming Internet-Trained Models
When artificial intelligence fails in clinical medicine, the culprit is often a mismatch between the curated datasets…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.