Studies
Ketamine and Psychedelics Share Immune Signaling Pathways Behind Rapid Antidepressant Effects
Treatment-resistant depression affects tens of millions worldwide, and the unexplained speed of ketamine's…
Longevity
Contracted 'Life Space' Associated with Cognitive Decline and Mortality Risk in Older Adults: Concept Analysis
How far an older adult ventures from home on a typical week turns out to be one of the most information-dense signals…
Studies
Three-Arm UK Trial Compares Compression Systems for Venous Leg Ulcer Healing
Venous leg ulcers affect roughly one percent of adults in high-income countries and consume disproportionate nursing…
Nutrition
Resveratrol + Tomato Pectin Synergy Rewires Gut-Liver Axis via FXR Signaling
Combining resveratrol (RSV) and tomato pectin (TP) in high-fat-diet mice produced synergistic metabolic benefits…
Supplements
Resveratrol Targets EGFR and PI3K-Akt to Block RSV in Silico
Computational screening of 261 resveratrol-associated targets against 1,196 RSV-related targets yielded 67 shared…
Supplements
Nitrate + Resveratrol Adds Liver-Specific Metabolic Gains Beyond Exercise Alone
In C57Bl/6N mice fed a high-fat diet for 6 weeks, aerobic exercise training (AET) alone reduced adipocyte size…
Longevity
5 Gut Fungi Genera Associated with Arterial Stiffness and Linked to Adrenergic/ACE Pathways in Observational Cohort
In a 763-participant cohort study using brachial-ankle pulse wave velocity measurement, ITS sequencing, and untargeted…
Nutrition
Mediterranean Diet Linked to Lower Risk Across 7 Cancer Types in Large Meta-Analysis
Across 126 studies enrolling more than 8 million participants, greater adherence to the Mediterranean diet was…
Nutrition
1.4M-Person Meta-Analysis Links Mediterranean Diet Adherence to 46–66% Lower Peripheral Artery Disease Risk
Across 87 studies encompassing over 1.4 million participants, higher Mediterranean diet (MD) adherence delivered…
Longevity
IL-8 and Exosomes Drive Senescence Spread in Rare Lung Disease via CXCR2
In an in vitro model of Lymphangioleiomyomatosis (LAM)—a rare destructive lung neoplasm—primary LAM/TSC cells lacking…
Studies
mTOR-Driven Glycogen Accumulation and Cellular Senescence Identified in All 13 Fibrofolliculomas
Every one of 13 archival fibrofolliculoma specimens displayed diastase-sensitive PAS-positive glycogen granules in…
Longevity
Immunosenescence Linked to SLE Pathogenesis via Senescent T Cells, Age-Associated B Cells, and SASP
SLE's peak incidence after age 48 masks a deeper truth: even young SLE patients exhibit accelerated immune aging…
Fitness
β2-Microglobulin Mediates ~38% of the Association Between Physical Activity and Slower Epigenetic Aging
In a cross-sectional analysis of 936 U.S. adults paired with single-cell RNA sequencing in exercised mice, higher…
Wellbeing
AQP4 Gene Variant Modifies Association Between Short Sleep and Tau Burden Before Age 60
Whether genetic makeup determines who is most harmed by chronic short sleep—at least in terms of Alzheimer's-related…
Longevity
Lipid Metabolism Emerges as Central Driver of Alzheimer's Neuroinflammation
The long-standing focus on amyloid plaques and tau tangles as the primary targets in Alzheimer's research may be…
Studies
Ivermectin Periconception Exposure Shows No Clear Adverse Pregnancy Signal in African Trials
For the hundreds of millions of women living in regions where ivermectin mass drug administration campaigns run…
PREPRINTFitness
~6,561 Steps/Day Linked to Optimal Quality of Life in Large Accelerometer Study
In a pooled analysis of 9,371 adults (median age 62, 47% female), thigh-worn accelerometry revealed curvilinear…
PREPRINTLongevity
21,522-Patient Algerian Cohort Reveals Opposing Sex-Specific CVD Risk Profiles
Among 21,522 Algerian adults in a nationwide cardiometabolic screening cohort, sex-stratified analysis revealed…
PREPRINTLongevity
78,113-Person 4D Cardiac AI Uncovers 26 Hidden Genetic Loci in Non-Myocyte Cells
Applying unsupervised deep learning to four-dimensional cardiac MRI from 78,113 UK Biobank adults, researchers…
PREPRINTLongevity
NOAC Use Associated With Lower Cognitive Impairment Risk in AF Patients, With Sex Differences in Dementia Subtype Associations
Among 66,885 Albertans aged 40+ diagnosed with incident non-valvular atrial fibrillation between 2012–2024, females…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.