Studies
Irradiated Tumor Fibroblasts Enter Senescence Yet Fuel Cancer Regrowth
Radiation therapy's failure to cure a third of advanced head and neck cancers has long puzzled oncologists, and this…
Studies
Explainable AI Skin Diagnostics Help Doctors But May Mislead Patients
The promise of AI-assisted diagnostics hinges on a critical assumption: that making AI more transparent improves…
Studies
Dual Microneedle Patch Closes Glucose-Insulin Loop in Diabetic Rats
Wearable closed-loop diabetes management has long been the holy grail of endocrinology engineering — a system that…
PREPRINTFitness
Peak Heart Rate Outperforms Cardiac Output in Predicting Walking Capacity for 211 Hypertensive Patients
Among 211 hypertensive patients assessed with impedance cardiography (ICG) during exercise, maximum heart rate (HRmax)…
PREPRINTLongevity
New Statistical Framework Identifies Stable Biomarkers for Post-Surgery Recovery in Older Adults
A new resampling-based statistical framework called Exploratory Stability Selection (ESS) was applied to the…
PREPRINTLongevity
Muscle Functional Capacity Modifies Association Between Adiposity and Sarcopenia in Two Large Cohorts
Across two large population-based cohorts — CHARLS (n=15,701 Chinese adults) and NHANES (n=10,730 Americans) — higher…
PREPRINTLongevity
Multimodal AI Model Achieves 0.91 AUC for Alzheimer's Differential Diagnosis
A Norwegian memory clinic cohort study combining MRI-derived imaging hazard scores, polygenic risk scores, cognitive…
Supplements
Liraglutide Reshapes Gut Microbiome in 4 Days, Reverses Within a Week
In diet-induced obese C57BL/6J mice treated with liraglutide for 14 days, 16S rRNA sequencing of 7.1 million sequences…
Studies
Semaglutide May Trigger Sarcopenia-Driven Hyperglycemia via mTOR-GLUT4 Suppression
A case-driven hypothesis built around a single 53-year-old male with T2DM proposes that semaglutide-induced sarcopenia…
Supplements
GLP-1 Agonists Linked to Lower Joint Replacement Infection Risk in Observational Studies
Preoperative use of GLP-1 receptor agonists — the drug class including semaglutide and liraglutide — is associated…
Studies
Coal Dust Nanoparticles Trigger Colitis via p16/p21 Senescence Switch in Gut
Coal dust-mimetic carbon nanoparticles (CNPs) delivered intranasally to rats over 4–12 weeks produced significant…
Longevity
SIRT1, GLP-1, and Gut Microbiota Converge on a Single Neurocardiac Axis
A mechanistic framework published in Medical Gas Research identifies APOE genotype, GLP-1 receptor agonism, SIRT1…
Studies
ASD Diagnosis Rates Surge: Broadened Criteria or Clinical Overreach?
The dramatic rise in autism diagnoses worldwide forces an uncomfortable question: are we getting better at identifying…
Longevity
Senescent Cells Drive HFpEF via SASP Inflammation: Senolytics Offer Targeted Hope
Heart failure with preserved ejection fraction is one of cardiology's most frustrating frontiers — affecting nearly…
Studies
Elastography Matches Biopsy Accuracy for Advanced Liver Fibrosis Detection
For the roughly one-third of adults globally carrying excess liver fat, the question of how severe the damage has…
Wellbeing
Adolescent Alcohol Use Associated with Higher Cyberbullying Victimization Risk via Loneliness and Nervousness Pathways
Understanding why some adolescents become cyberbullying targets is critical for designing effective interventions…
Studies
Blood Biomarkers GFAP and NfL Predict Silent MS Progression Under Fingolimod
For people living with multiple sclerosis, the gap between visible relapses and the silent, cumulative damage…
Studies
Ultrasound Brain Stimulation Lowers Heat Pain Threshold via Somatosensory Cortex
Pain modulation without drugs or invasive procedures remains one of the most sought-after frontiers in clinical…
Studies
Foodborne Pathogens Kill 265,000 Annually With 7× Regional Mortality Disparity
The gap between what wealthy and low-income nations experience from contaminated food is not merely statistical — it…
Studies
Recent Developments in Levodopa Delivery and Parkinson's Disease Treatment
For the estimated ten million people worldwide living with Parkinson's disease, the central frustration of treatment…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.