Longevity
Metabolic Atlas Reveals Alpha-Ketoglutarate and Novel Aging Drivers Across Organs
The quest to understand why organs deteriorate at different rates during aging has gained new precision through compreh…
Wellbeing
Psilocin Triggers Sustained Brain Changes Through Novel Non-5-HT2A Pathway
The growing clinical interest in psilocybin for depression treatment has largely focused on its dramatic acute effects,…
Studies
15-PGDH Enzyme Inhibition Triggers Cartilage Regeneration in Arthritic Joints
Blocking 15-hydroxy prostaglandin dehydrogenase (15-PGDH) with a small-molecule inhibitor reversed cartilage degenerati…
Fitness
Resistance Training Mechanisms Show Mixed Translation from Lab to Clinic
Resistance training activates distinct biological pathways in aging muscle, but their translation from laboratory to cl…
Supplements
Resveratrol-Curcumin Combinations Boost Alzheimer's Drug Efficacy to 97%
Combining FDA-approved Alzheimer's antibodies aducanumab and lecanemab with resveratrol and curcumin achieved 89-97% in…
Wellbeing
Nitric Oxide Chemical Modification Disrupts mTOR Signaling in Autism Models
Understanding autism spectrum disorder's molecular origins could transform therapeutic approaches for millions of famil…
PREPRINTLongevity
Heart Failure Subtypes Show Opposite Damping Patterns Despite Similar Stiffness
Advanced cardiac imaging analysis of 225 patients reveals that heart failure with preserved ejection fraction (HFpEF) a…
Wellbeing
Rare 13-18 Hz Leg Tremor Reveals Network Brain Disorder
Standing upright becomes an ordeal for those with orthostatic tremor, a neurological puzzle that transforms the simple…
Wellbeing
Air Pollution Associated with Higher Seasonal Pollen Concentrations Across Multiple Plant Types
Growing respiratory allergy rates may reflect a troubling synergy between industrial emissions and natural allergens th…
Wellbeing
AI Chatbots Show Promise for Mental Health Support in HIV-Vulnerable Communities
Mental health interventions could gain critical traction in underserved populations through artificial intelligence pla…
Studies
Rural Emergency Surgery Matches Urban Trauma Center Outcomes
Emergency abdominal surgery in remote locations has long sparked debate about whether critically injured patients shoul…
Studies
Coronaviruses Hijack Host tRNA Modifications to Boost Viral Protein Production
The mystery of how coronaviruses efficiently manufacture proteins despite using genetically 'suboptimal' building block…
Studies
PRPF31 Mutation Triggers Early Müller Glia Activation Before Photoreceptor Loss
Inherited blindness may begin with subtle cellular distress signals years before patients notice vision problems, chall…
Studies
Mouse Breast Cancer Study: Cancer Stem Cells Use ISG15 Protein to Modulate Immune Defense During Metastasis
The immune system's failure to prevent metastasis may hinge on a single protein that cancer stem cells weaponize to cor…
Longevity
Astrocytes Undergo Metabolic Reprogramming During Ketone Therapy Interventions
Astrocytes—the brain's primary support cells—undergo extensive metabolic and structural changes when exposed to ketone…
Longevity
Natural Flavonoid Dihydromyricetin Targets Senescent Cells via PRDX2 Mechanism
Dihydromyricetin, a flavonoid found in Ampelopsis grossedentata (vine tea), demonstrates sophisticated senotherapeutic…
Longevity
Dietary Restriction Activates Seven Key Anti-Aging Pathways Including Autophagy
Dietary restriction triggers coordinated activation across seven distinct longevity pathways: autophagy, FGF21 signalin…
Longevity
DunedinPACE Epigenetic Clock Outperforms 13 Other Aging Biomarkers for Mortality Prediction
Among 14 consensus aging biomarkers tested in 1,083 German adults aged 60-80 over 7.4 years, the DunedinPACE epigenetic…
Wellbeing
Cognitive Training Shows Promise for Long COVID Brain Fog Treatment
Brain fog sufferers from long COVID may finally have evidence-based treatment options that can meaningfully improve the…
Wellbeing
Corn Protein Alpha-Zein Triggers Specialized Immune Tolerance Cells in Gut
The discovery that specific food proteins actively train our immune system to remain calm could reshape understanding o…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.