Studies
Oral TYK2/JAK1 Inhibitor Brepocitinib Achieves Skin Remission in Phase 3 Dermatomyositis Trial
Dermatomyositis is one of the most treatment-resistant inflammatory diseases affecting both skin and muscle, and for…
Studies
Alpha-Gal IgE Seroprevalence Mapped Across 10 States in First Blood-Donor Survey
Millions of Americans may carry a tick-triggered antibody that makes red meat dangerous — yet most have no idea…
Wellbeing
Gut Microbiome Metabolites Linked to Cortical GABA-Glutamate Balance in Humans
The assumption that gut-brain communication is largely an animal-model phenomenon has long frustrated translational…
Wellbeing
Digital App Suite Reduces Anxiety (But Not Significantly Depression) in Breast Cancer Survivors at 12 Months
Psychological distress following a breast cancer diagnosis is not a peripheral concern — it shapes quality of life…
Studies
Gut Fungal Imbalance in IBD: Candida's Role Remains Contested
For the millions living with Crohn's disease or ulcerative colitis, the microbiome narrative has long centered on…
Studies
VR Defocus Training Slows Childhood Myopia Progression in 6-Month Trial
Myopia is advancing at near-epidemic rates in East Asia, with children increasingly diagnosed before age ten — and…
Longevity
PROMETHEUS Trial Tests Gerotype-Personalized Supplements and Exercise Over Eight Weeks
Precision medicine for aging is moving beyond one-size-fits-all recommendations, and a new feasibility trial is…
Studies
CRBN Molecular Glue Selectively Degrades KAT2A Without Canonical Degron Recognition
A fundamental assumption in targeted protein degradation has been that the target protein must display a recognizable…
Longevity
Tiny Mitochondrial Peptide STMP1 Links Cristae Collapse to Cardiac Aging
For decades, heart failure research has focused on contractile proteins, ion channels, and neurohormonal pathways…
Studies
Grape Nanoparticles Deliver Resveratrol to Block NPC via FASN/MAPK Suppression
Grape peel-derived exosome-like nanoparticles (GELNs) — isolated via ultracentrifugation — effectively shuttle…
Nutrition
Chaga-Derived DBL Protects Poultry Gut from LPS Injury via Mitophagy Restoration and Apoptosis Suppression
A polyphenolic compound called 3,4-Dihydroxybenzalacetone (DBL), extracted from the medicinal fungus Inonotus obliquus…
Supplements
Grape Polyphenol Trio Tested in RCT for Stress Resilience at Three Doses
A parallel-arm, double-blind, placebo-controlled trial at Mount Sinai's Depression and Anxiety Discovery Center is…
Supplements
Resveratrol Blocks Pyrethroid Pesticide Cardiotoxicity via ROS Suppression in Zebrafish
At environmentally relevant concentrations of 3.5–7 μg/L, the type II pyrethroid pesticide fenvalerate (FEN) caused…
Longevity
ABL1 Kinase Drives Post-Op Cognitive Decline via mTOR/ULK1 Autophagy in Aged Mice
ABL1 tyrosine kinase directly binds mTOR and, in aged mice modeling postoperative cognitive dysfunction (POCD), drives…
Longevity
FGF21 Reverses Stem Cell Aging via TFE3-Autophagy-SIRT1-mTOR Cascade
FGF21 (fibroblast growth factor 21) reverses senescence in aged human adipose-derived mesenchymal stem cells (ASCs) by…
Longevity
Single-Cell Analysis Suggests MMC May Induce SASP-Like State in Some Surviving Fibroblasts After Glaucoma Surgery
Trabeculectomy's gold-standard adjunct mitomycin C (MMC) kills most fibroblasts to prevent scarring—but single-cell…
Supplements
100mg Daily Fisetin Targets suPAR Inflammation Marker in First RCT Protocol
A Danish triple-blind, randomised, placebo-controlled trial is testing whether 100 mg of oral fisetin daily for 7…
Longevity
Delayed Senescent Cell Clearance at 4 Months Reverses Radiation-Induced Aging in Mice
Using the INK-ATTAC transgenic mouse model, selective elimination of p16Ink4a-positive senescent cells at 4 months…
Studies
TRAVERSE Trial Clarifies TRT Cardiac Safety While Flagging Secondary Risk Signals
For over a decade, clinicians prescribing testosterone replacement therapy to older hypogonadal men have operated in…
Studies
AI Transformer Model Outperforms Cox Methods for Chinese Cardiovascular Risk
Cardiovascular risk calculators built on decades-old statistical frameworks may be systematically underserving more…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.