PREPRINTStudies
46% of Nations Still Twice Their Regional Frontier in Child Pneumonia Survival After 33 Years
Analyzing Global Burden of Disease 2023 estimates across 204 countries, this study tracked each nation's…
PREPRINTStudies
Childhood Respiratory Deaths Diversified Across 29 Pathogens While Concentrating in Poverty Zones
Across 1990–2023, childhood respiratory infectious mortality — spanning 26 lower respiratory infection etiologies plus…
PREPRINTStudies
IV Iron in Pregnancy Cuts Stillbirth Risk 83% in Pakistani Anaemia Cohort
Among 1,715 pregnant Pakistani women with haemoglobin below 10 g/dL, intravenous iron administered within 14 days of…
PREPRINTStudies
Quadriceps Ultrasound Achieves 100% Sensitivity Ruling Out Malnutrition in Heart Failure
Measuring quadriceps femoris muscle (QFM) thickness via 2D ultrasound at the two-thirds femur point without probe…
Longevity
GH Receptor Antagonism Extends Mouse Lifespan by Up to 265 Days
Transgenic mice expressing a growth hormone receptor antagonist (GHA) — engineered via a glycine-to-lysine mutation at…
Studies
Blocking Kir7.1 Channel Reverses Clozapine Weight Gain Without Losing Antipsychotic Effect
Weight gain from antipsychotic medications is one of psychiatry's most stubborn clinical problems — it drives…
Wellbeing
Severe Breathlessness Doubles Loneliness Risk in Adults Over 50
Loneliness is increasingly recognized as a clinical outcome in its own right, yet its intersection with respiratory…
Fitness
Six Months of Exercise Slows Hippocampal Atrophy and Reshapes Sleep-Brain Connectivity in Alzheimer's
For the millions of adults navigating early Alzheimer's disease or mild cognitive impairment, the question of whether…
Studies
Blood-Level Statin Monitoring Reveals Near-Perfect AMI Trial Adherence With Clear Plaque Benefits
For decades, cardiovascular prevention research has wrestled with a stubborn confound: patients in trials who say…
Fitness
Lifelong Athletic Training Slows But Cannot Stop Age-Related Physical Decline
For adults seeking evidence-based strategies to preserve physical capacity into old age, the master athlete model…
Studies
Metastatic Prostate Cancer Survival Gains Outpace Localized Disease Over 14 Years
The biggest survival gains in prostate cancer over the past decade have not come from refining care for early-stage…
Supplements
Oral Semaglutide's 0.4–1% Bioavailability: SNAC Workaround and What Comes Next
Oral semaglutide, despite its commercial availability, achieves only 0.4–1% absolute bioavailability under strict…
Supplements
Tirzepatide Breaks Refractory Diabetes Barrier Where GLP-1 Alone Failed in PWS
A woman with genetically confirmed Prader-Willi syndrome (15q11.2-q13.1 heterozygous deletion, verified by DNA…
Longevity
GLP-1R Agonist Exendin-4 Halts Implant Bone Loss via Dual Anti-Inflammatory/Anabolic Mechanism
A GLP-1 receptor agonist best known for diabetes and weight management demonstrates a compelling orthopedic…
Longevity
GLP-1 Agonists Cut MACE Risk 37% vs. Spironolactone in Resistant Hypertension
Among 4,153 propensity-matched adults with resistant hypertension and overweight/obesity, initiating GLP-1 receptor…
Supplements
Whey Protein Beats HMB for Grip Strength in Sarcopenic Elders: Meta-Analysis
Across 7 high-quality RCTs enrolling 472 older adults with sarcopenia, combining strength training with whey protein…
Longevity
MERCS Dysfunction Proposed as Upstream Driver of Microglial Senescence in Alzheimer's
Mitochondria-endoplasmic reticulum contact sites (MERCS) coordinate calcium shuttling, mitochondrial fission-fusion…
Wellbeing
Rural Brain-Health Screening Program Uncovers High Dementia Risk Factor Burden
Cognitive decline does not announce itself equally across geography. Rural adults — who represent nearly 20% of the…
Studies
Neonatal Fibroblasts Outperform Adult Cells in Beta-Cell Reprogramming Efficiency
For the millions living with insulin-dependent diabetes, the prospect of generating functional beta cells outside the…
Studies
Transvaginal Ultrasound Quantifies Retrograde Menstruation Via Pelvic Fluid Tracking
Retrograde menstruation — the backflow of menstrual blood through the fallopian tubes into the pelvic cavity — has…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.