Distant Protein Mutation Alters Ligand Binding by Modulating Conformational Ensemble Without Changing Overall Structure
Researchers discovered that single amino acid changes located far from a protein's binding site can dramatically alter…
Researchers discovered that single amino acid changes located far from a protein's binding site can dramatically alter…
A novel imaging technique combines TROP2 protein targeting with near-infrared fluorescence to provide real-time…
Researchers demonstrate that artificial intelligence systems' tendency to generate false information can be…
Researchers identified Mfsd2a as a critical transporter that maintains skin barrier integrity by regulating…
Researchers have identified specific plastid enzymes that catalyze the challenging C14β-hydroxylation step in…
Maternal obesity activates a cascade of biological mechanisms that program offspring for lifelong metabolic…
Orforglipron demonstrates superior metabolic outcomes compared to oral semaglutide in head-to-head trials, achieving…
An off-the-shelf neoantigen vaccine targeting Lynch syndrome has demonstrated both safety and immunogenicity in…
A prospective study tracking 146 adults with treatment-resistant focal epilepsy over 18-36 months found progressive…
Analysis of UK health records using machine learning algorithms has identified distinct clinical subtypes that span…
Activating the bone morphogenetic protein receptor ALK3 in cartilage cells paradoxically worsened skeletal defects in…
Scientists developed lanthanide nanoparticles that use near-infrared light to selectively reprogram M2-like…
Analysis of 171 studies across two decades reveals 59 distinct barriers and facilitators affecting oral nutritional…
Investigators tested a novel miniaturized vagus nerve stimulator—50 times smaller than existing devices—that delivers…
Brain imaging reveals that both schizophrenia patients and their healthy siblings exhibit disrupted neural networks…
Adult vaccination appears to fundamentally rewire aging immune systems beyond simple pathogen protection, triggering…
Researchers propose 'immunofitness' as a measurable target for healthy aging, emphasizing vaccination's capacity to…
Yang-style tai chi delivered through unsupervised online videos produced clinically meaningful improvements in knee…
The Muscle Ageing and Sarcopenia Study (MASS) Lifecourse has established a comprehensive database of muscle biopsies…
Analysis of nearly 100,000 men with benign prostatic hyperplasia found alpha-blockers increased cardiovascular events…
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