Studies
Agricultural Plant Hormone BAP Drives Weight Loss via MEK/ERK Pathway in Obese Mice
The obesity pharmacology landscape is dominated by GLP-1 receptor agonists and other agents with significant…
Nutrition
Abdominal Obesity Plus Severe Vitamin D Deficiency Doubles Mortality Risk After 50
For adults navigating midlife health decisions, the relationship between body composition and micronutrient status…
Studies
Estrogen-Only Hormone Therapy Linked to 35% Lower Alzheimer Pathology at Autopsy
For the roughly one in five women who will develop Alzheimer's disease, the window around menopause may represent a…
Fitness
Meta-Analysis: Regular Stair Climbing Associated with 39% Lower Cardiovascular Mortality Risk
For the millions of adults who struggle to meet formal exercise guidelines, the staircase may represent one of the…
Wellbeing
Chemokine Networks Drive Alzheimer's Neuroinflammation Differently by Sex and Infection
Understanding why some brains succumb to Alzheimer's disease while others remain resilient despite similar amyloid…
Longevity
AI Reads Tissue Slides to Build 40-Organ Aging Clock Network
Most aging clocks built to date rely on blood biomarkers or DNA methylation patterns, treating the body as a single…
Studies
Childhood Maltreatment Linked to Amplified Pregnancy Inflammatory Stress Response and Preterm Birth Risk
Understanding why adverse childhood experiences echo across generations into offspring health has been one of…
Fitness
Exercise Slows Ovarian Aging Via Adiponectin Signaling, Mouse and Human Data Show
Ovarian aging is one of the least modifiable dimensions of female biology — it determines reproductive lifespan…
Longevity
Myokines Bridge Muscle Loss and Cognitive Decline via Six Key Molecular Pathways
The assumption that muscle loss and brain aging are parallel but independent processes is increasingly untenable. A…
Wellbeing
England's 135,000-Person Loneliness Map Reveals Surprising Age and Geography Patterns
Loneliness has long been treated as an invisible condition — felt individually, rarely measured systematically. A…
Studies
DAPK1 Kinase Emerges as Multi-Pathway Target in Alzheimer's Pathogenesis
Most Alzheimer's disease therapies have targeted single pathological hallmarks — amyloid plaques or tau tangles — yet…
Longevity
Adiponectin Links Physical Activity to Delayed Ovarian Aging in Humans and Mice
For women thinking about reproductive longevity and menopause timing, the question of whether lifestyle choices can…
Studies
CRISPR and Biomaterials Converge to Build Immune-Evasive Islet Grafts
For the roughly two million people living with type 1 diabetes globally, the immune system is both cause and obstacle…
Studies
Multinational Validated Model Predicts Severe Asthma Exacerbation Risk Individually
Predicting which severe asthma patient will land in the emergency room within the next year has long been a clinical…
PREPRINTSupplements
NMNH-Ca Raises Whole-Blood NAD+ 39.9 µM at 500mg Over 90 Days
A 90-day randomized, double-blind, placebo-controlled phase I trial in 80 healthy adults aged 40–65 tested oral…
Studies
GLP-1 Drugs Cut Sleep Apnea Severity, But Cardiovascular Proof Remains Elusive
Incretin-based therapies — particularly liraglutide and tirzepatide — demonstrate meaningful reductions in…
Longevity
Rationale Paper Highlights Gq/11 Bias in MC4R Signaling for Future Obesity Drug Design
High-resolution cryo-electron microscopy of the setmelanotide-MC4R-Gq complex reveals that melanocortin-4 receptor…
Longevity
Circumventricular Organs Identified as Key Gateway for GLP-1 Weight-Loss Drug Action
GLP-1 receptor agonists — now the dominant pharmacological approach to obesity — achieve sustained weight loss…
Studies
Semaglutide Tops 4 GLP-1 Drugs Linked to Reversible Gastroparesis in 13 Cases
Across 12 case reports encompassing 13 patients, GLP-1 receptor agonists — predominantly semaglutide, followed by…
Studies
Computational Electrode Optimization Boosts Glioblastoma TTFields Intensity by Up to 34%
For patients with glioblastoma — a brain cancer with a median survival under 18 months even with standard care…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.