Longevity
Gut Microbiome Metabolites Predict Cardiovascular Disease Through Kidney-Heart Axis
Gut bacterial metabolism of aromatic amino acids phenylalanine and tyrosine generates metabolites that correlate with…
Longevity
mTORC2 Uses Protein Structure, Not Sequence, for Akt Phosphorylation
Researchers discovered that mTORC2 recognizes its key substrate Akt through distant three-dimensional protein…
Longevity
New Method Tracks Epigenetic Metabolites Including SAM, Acetyl-CoA
Researchers developed a sophisticated analytical method that simultaneously tracks 42 metabolites crucial for…
Longevity
Pyruvate Dehydrogenase Inhibition Selectively Kills Senescent Cells In Vitro; Combination Therapy Clears Them and Improves Function in Aged Mice
Proteomic analysis of radiation-induced senescent human fibroblasts revealed 178 proteins with 4-fold abundance…
Studies
Wound Bacteria Associated with Honey Treatment Outcomes in Diabetic Foot Ulcers
The unpredictable nature of honey-based wound therapy may finally have an explanation. Diabetic foot ulcers affect…
Wellbeing
Head-Mounted Video Display Improves Childbirth Experience and Reduces PTSD Symptoms in C-Section Pilot Study
Birth trauma affects nearly one in three mothers following cesarean delivery, with immediate skin-to-skin contact…
Longevity
Glycolytic Metabolite PEP Dampens Age-Related Inflammation Through cGAS-STING Pathway
Age-related inflammatory damage may have found an unexpected metabolic brake. The discovery that phosphoenolpyruvate…
Longevity
Caloric Restriction Mechanisms Show Promise Despite Mixed Human Evidence
The promise of extending healthy lifespan through eating less has captivated researchers for decades, yet translating…
Wellbeing
Left Hippocampus Size Predicts Antidepressant Response in Depression Patients
Identifying which depression patients will respond to antidepressants remains one of psychiatry's most pressing…
Wellbeing
AI Analysis Reveals Five Distinct Subtypes Each for Alzheimer's and Parkinson's Before Diagnosis
The traditional view of Alzheimer's and Parkinson's diseases as single entities may be fundamentally flawed, with…
Studies
Partial Recovery Metric Shows Quality of Life Gains in Polysubstance Users
Traditional addiction recovery metrics often fail those battling multiple substances simultaneously, creating an…
Longevity
Glycolytic Metabolite PEP Controls Inflammatory Aging Through cGAS Inhibition
The discovery that a single metabolic molecule controls the inflammatory cascade of aging could reshape how we…
Longevity
SIRT6 Protein Controls Mitochondrial Function Through Dual Nuclear-Mitochondrial Pathway
The discovery that cellular aging processes operate through coordinated nuclear-mitochondrial communication pathways…
Wellbeing
Clinician Attitudes Drive Heart Failure Drug Adoption Gaps
Heart failure affects over 6 million Americans, yet a striking implementation gap persists between evidence-based…
Longevity
GLP-1 Drugs Show Broad Organ Protection Beyond Diabetes Control
The expanding therapeutic reach of GLP-1 medications signals a potential shift from single-target treatments to…
PREPRINTStudies
Heart Failure Quality Program Associated With 3-5% Lower Mortality in Medicare Patients
Hospital participation in the Get With The Guidelines-Heart Failure program was associated with a 0.15-point increase…
PREPRINTWellbeing
Childhood Cancer Treatment Impairs Endothelial Repair Through Senescent Cell Accumulation
Researchers tracked endothelial injury markers in 48 children with leukemia and lymphoma receiving anthracycline…
PREPRINTStudies
Blood Pressure Variability Improves CVD Risk Prediction (C-Index from 0.716 to 0.833-0.837)
Blood pressure variability between medical visits dramatically outperformed single readings in predicting…
PREPRINTWellbeing
AI Chatbot Trial Tests Quality of Life in 480 Atrial Fibrillation Patients
A randomized controlled trial will evaluate whether a conversational AI chatbot can improve quality of life in 480…
PREPRINTWellbeing
At-Home Digital Cognitive Screening Shows 78.5% Completion Rate
A pilot study of 32 older adults found that at-home digital cognitive screening achieved a 78.5% completion rate when…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.