Longevity
PANoptosis Cell Death Pathway Emerges as Cardiac Aging Target
Heart aging represents one of the most consequential challenges facing an increasingly long-lived population, as…
Studies
FACT-BET Inhibitor Combination Extends Survival in Aggressive Pediatric Glioma Models
Pediatric brain cancer research has achieved a breakthrough that could transform treatment of one of childhood's most…
Nutrition
Whey Protein Shows Mixed Results for Muscle Preservation During Weight Loss
The conventional wisdom that protein supplementation uniformly protects muscle during weight loss faces new scrutiny…
Studies
Gene Editing Offers Prospect of Single-Dose Treatment for Transthyretin Amyloid Cardiomyopathy
A once-fatal heart condition that progressively destroys cardiac tissue may soon become manageable with a single…
PREPRINTStudies
Fontan Surgery Conduit Size Doesn't Predict Exercise Capacity in 561 Patients
A multicenter analysis of 561 individuals with Fontan circulation found that surgical conduit size, ventricular…
PREPRINTWellbeing
Health Behaviors, Especially Insufficient Physical Activity, Explain 40% of Excess CVD Risk in Lower Occupational Classes Among Finnish Municipal Workers
Finnish municipal employees in lower occupational classes showed 50% cardiovascular disease rates versus 46% in higher…
PREPRINTStudies
Advanced cardiac centers associated with 56-67% lower odds of cardiogenic shock mortality
A nationwide analysis of over 1.1 million cardiogenic shock hospitalizations reveals dramatic mortality differences…
PREPRINTStudies
GLP-1 Receptor Agonists Outperform SGLT2 Inhibitors for Heart Failure Outcomes
Analysis of electronic health records from Stony Brook University Hospital revealed that GLP-1 receptor agonists…
PREPRINTLongevity
Biological Age Acceleration Predicts Faster Disease Progression by 2.84 Years
Analysis of 433,911 UK Biobank participants reveals that biological age acceleration—measured through PhenoAge and…
Longevity
Skeletal Muscle FoxO Proteins Protect Liver from Fat Accumulation During Fasting and High-Fat Diets in Mice
Skeletal muscle-specific deletion of FoxO1, FoxO3, and FoxO4 transcription factors in mice dramatically worsened fatty…
Longevity
Vascular Aging Drives Multimorbidity Through IL-1β Pathway, Cellular Senescence
Three core mechanisms drive vascular aging: epigenetic drift, chronic low-grade inflammation particularly through the…
Wellbeing
Brain Injuries From Intimate Partner Violence Linked to Substantially Higher Rates of Chronic Health Problems
Brain injuries sustained during intimate partner violence create a devastating cascade of long-term health…
Wellbeing
Maternal Stress Disrupts Placental Iron Transfer Specifically in Female Fetuses
The intersection of maternal stress and fetal brain development has gained new clarity through a discovery that could…
Nutrition
Food Literacy Training Shows Modest Gains Despite Persistent Racial Disparities
Vulnerable diabetic populations face complex barriers to healthy eating that extend far beyond simple nutrition…
Nutrition
Diet-Related Heart Disease Deaths Drop 44% Globally Despite 4 Million Annual Fatalities
The largest modifiable threat to heart health isn't smoking or sedentary living—it's what's missing from dinner plates…
Studies
PFAS Chemical Exposure Shows Minimal Impact on COVID Vaccine Effectiveness
Chemical contamination concerns just gained new clarity for vaccine-dependent immunity. Despite widespread fears that…
Studies
Engineered Ferritin Enables On-Demand MRI Tracking of Transplanted Heart Cells
Monitoring transplanted cells in the heart has long challenged regenerative medicine researchers, who struggle to…
Studies
Dialysis Patients Without Private Transport 47%-58% Less Likely to Transition to Home Dialysis
Transportation barriers create an unexpected paradox in kidney care that affects thousands of dialysis patients…
Studies
Zirconium-89 and Iodine-124 Optimize Brain Amyloid Detection via PET
Brain imaging of Alzheimer's disease may advance significantly through optimized radionuclide selection for…
Studies
Microbial Metabolite 4-GBA Repairs Gut Barrier Through SLC36A1 Transporter Activation
The discovery of a precise molecular circuit governing gut health could revolutionize inflammatory bowel disease…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.