Studies
Host Protein TBC1D23 Found Essential for AAV Gene Therapy Vector Trafficking
Gene therapy's clinical promise depends on a deceptively simple premise: that a viral vector can reliably navigate the…
Studies
Enzyme Evolution Reveals IL4I1's Immune-Modulating Aromatic Amino Acid Specificity
Understanding how immune enzymes acquired their precise biochemical identities matters because those identities…
Studies
Water Channels Inside Amyloid Fibrils May Reshape Understanding of Disease Aggregates
The dominant model of amyloid fibrils — the misfolded protein aggregates implicated in Alzheimer's, Parkinson's, and…
Studies
Hydrophobic Base Pairs Drive RNA Polymerase Function Without Hydrogen Bonds
A foundational assumption in molecular biology — that accurate genetic transcription depends on hydrogen bonding…
Studies
First Near-Complete Foveal Retina Connectome Maps 50+ Neuron Types
Understanding how the eye converts light into the rich visual experience humans rely on has long been limited by our…
Studies
Dual Phosphatase Blockade Restores Tumor Interferon Sensitivity, Boosting Immunotherapy Response
Immune checkpoint blockade has transformed oncology, yet the majority of cancer patients derive little or no lasting…
Longevity
Experimental Evolution Links Boldness, Lifespan, and Reproduction via Gene Networks
One of evolutionary biology's most contested ideas — that boldness, longevity, and fertility are biologically yoked…
Studies
Gene Therapy Activating NRF2 Shields Retinal Vessels via GDF15 Signal
Age-related macular degeneration remains one of the leading causes of irreversible vision loss in older adults, and…
Studies
Adult-Born Neuron Circuit Integration Drives Brain Injury Recovery in Regenerative Models
One of the most stubborn truths in neuroscience has been that the adult human brain cannot meaningfully replace…
Longevity
Lancet Framework Reframes Fall Prevention as Resilience Across Three Mobility Levels
Falls remain one of the leading causes of injury-related death and disability in adults over 65, yet decades of…
Longevity
Paired Carer-Patient Programs Show Mixed Results for Frailty and Multimorbidity
As global populations age and multimorbidity becomes the norm rather than the exception, the question of how to…
Longevity
CBT for Insomnia Linked to Slower Biological Aging via DunedinPACE Epigenetic Clock
Chronic insomnia does more than exhaust the body — it may accelerate the molecular machinery of aging itself. The idea…
Longevity
Stopping Statins After 75 Shows No Mortality Penalty in Landmark Trial
For the millions of older adults quietly questioning whether a pill they've taken for decades still earns its place in…
Longevity
Metformin Adds No Physical Function Benefit Beyond Lifestyle Alone in Obese Older Adults
For decades, metformin has attracted intense interest as a potential longevity-extending compound beyond its…
Longevity
Dementia Risk Past 90 Tied to Race and APOE-Sex Interactions
For decades, the implicit assumption in aging research has been that surviving to extreme old age confers a kind of…
Studies
Preoperative IV Iron Cuts Transfusion Risk in Non-Anaemic Cardiac Surgery Patients
Blood transfusions during cardiac surgery carry underappreciated risks — from immune sensitization to increased…
Longevity
Lancet Commentary Questions Metformin's Anti-Aging Promise in Frail Elderly
The intense scientific interest in repurposing a decades-old diabetes drug as a broad anti-aging intervention has…
Longevity
APOE-Dementia Link Shows Altered Dynamics in Adults Past Age 90
Among the most consequential open questions in dementia research is whether the genetic risk architecture established…
Wellbeing
Residential PM2.5 Exposure Linked to Impulsive Decision-Making in Middle-Aged Adults
The idea that outdoor air quality might quietly reshape how the aging brain weighs future rewards against immediate…
Studies
AYA Cancer Survivors Face Elevated Long-Term Respiratory Death Risk Decades Later
For the roughly 90,000 adolescents and young adults diagnosed with cancer each year in the United States, surviving…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.