PREPRINTLongevity
Atrial Fibrillation Raises Injurious Fall Risk 89% in Hypertensive Adults
Among 8,807 hypertensive adults enrolled in the SPRINT trial, atrial fibrillation (AF) was independently associated…
PREPRINTLongevity
Blood Pressure Drives 71% of Global CVD Mortality Decline; BMI Acts Entirely Through Metabolic Intermediaries
Age-standardized cardiovascular mortality fell from 340.2 to 258.4 deaths per 100,000 globally between 2000 and 2023…
PREPRINTLongevity
Shunt Insertion Angle Predicts Thrombosis Risk in 8-12% of Infant Heart Surgeries
In 10 infant patients with cyanotic or single-ventricle heart disease, patient-specific computational fluid dynamics…
Longevity
GLP-1 Therapies Show Promise for Women's Cardiometabolic Risk, But Sex-Specific Data Remain Scarce
Women's cardiometabolic risk from obesity follows distinct hormonal trajectories—from menarche through menopause—that…
Longevity
Gut Dysbiosis Depletes SCFAs, Driving Bone Loss in Elderly via NF-κB Inflammation
Aging-associated gut dysbiosis — marked by depletion of short-chain fatty acid (SCFA)-producing bacteria, accumulation…
Wellbeing
Cumulative IPV Relationships Compound Depression and Trauma Symptoms in Both Partners
The mental health toll of intimate partner violence is often framed around individual incidents, but the cumulative…
Studies
Interleaved Learning Advantage Survives Rigorous Forced-Choice Memory Test
One of the most widely cited findings in cognitive science — that mixing different subjects during study sessions…
Studies
SARM1 Axon-Degeneration Enzyme Not Directly Activated by Double-Stranded DNA
Understanding what switches on the axon self-destruction program matters enormously for conditions ranging from…
Studies
Rosette Cell Clusters Drive Pancreatic Cancer Organoid Self-Assembly Mechanics
Understanding how cancer cells self-organize into tissue-like structures may be one of the most underappreciated…
Wellbeing
Frontolimbic Brain Wiring From Birth Shapes Cognition Under Adversity
How the brain's emotional and cognitive circuits wire themselves across the first two decades of life has profound…
Studies
Tumor-Immune Spatial Patterns Yield Transcriptomic Biomarkers Predicting Cancer Progression
Understanding why some tumors respond to immunotherapy while others evade it remains one of oncology's most pressing…
Supplements
Gut Bacterium's Anti-Inflammatory Power Traced to Single Metabolite
Understanding why the same probiotic species produces dramatically different health outcomes across individuals has…
Studies
Antiviral Protein MAVS Doubles as Hypoxia Survival Regulator via Mitochondrial ROS
A protein long confined in immunology textbooks to antiviral defense turns out to play a parallel role in one of cell…
Studies
crRNA Scaffold Mutation Solves Key Sensitivity Tradeoff in One-Pot CRISPR Diagnostics
Rapid pathogen detection sits at the intersection of molecular biology and public health preparedness — and a…
Studies
Short AR Gene Repeats Amplify Androgen-LSD1 Signaling, Rewiring Prostate Cancer Metabolism
For decades, the androgen receptor's CAG repeat polymorphism has sat at the edge of prostate cancer research…
Studies
Statins Block Melanoma's Shape-Shifting Migration Via Cholesterol-Piezo1 Axis
Most cancer treatments target tumor growth directly, but metastasis — the spread of cancer cells through tissue — is…
Studies
Exosome Trafficking Controls Brown Fat Heat Production, Revealing Metabolic Pathway
Understanding why some people burn calories more efficiently than others has long frustrated metabolic researchers…
Longevity
Polyamines and eIF5A Protein Linked to Cellular Quality Control During Ribosome Stalling
Protein quality control is one of biology's most elegant unsolved problems: how does a cell simultaneously permit wide…
Studies
Mitochondrial Stress Redirects B12 Chaperone to Boost Homocysteine-Clearing Enzyme
Homocysteine elevation is one of the most consistently replicated cardiovascular and cognitive risk markers in aging…
Studies
FOXR1 Transcription Factor Identified as CD8+ T Cell Antitumor Brake via CRISPR Screen
Understanding why immune cells lose their cancer-fighting capacity is one of the central puzzles in oncology. T cell…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.