PREPRINTWellbeing
Heart Septal Spiral Pattern Predicts Arrhythmia Risk in Cardiomyopathy
Advanced 3D cardiac imaging of 102 dilated cardiomyopathy patients revealed that loss of the heart's normal spiral sept…
Studies
NDGA Compound Shows Enhanced Prostate Cancer Inhibition When Combined with EZH2 Blockers
Nordihydroguaiaretic acid (NDGA), a lignin compound from creosote bush, demonstrates significantly enhanced anti-cancer…
Studies
Thyroid Hormone Analog Resmetirom Reverses Multiple MASH Pathways
Transcriptomic analysis reveals that resmetirom, a selective thyroid hormone receptor-beta agonist, simultaneously targ…
Studies
Bispecific T-Cell Engagers Reverse Severe Autoimmune Disease in Small Trial
Ten patients with severe, treatment-resistant autoimmune conditions—five with antisynthetase syndrome and five with sys…
Studies
Plasma p-tau217 Clock Accurately Forecasts Alzheimer's Symptom Timeline
Researchers developed predictive algorithms using plasma p-tau217 levels to forecast when cognitively healthy individua…
Longevity
Midlife Visceral Fat Expansion Isn't Universally Harmful, Nature Review Reveals
White adipose tissue accumulation around abdominal organs during midlife follows predictable patterns, but its metaboli…
Longevity
Liver-derived ApoE protein blocks bone healing in aged mice
Researchers identified apolipoprotein E (ApoE) as a key mechanism behind age-related bone healing impairment. In 24-mon…
Wellbeing
Combined Lifestyle Plus Supplement Interventions Show Mixed Dementia Prevention Results
A systematic analysis of twelve randomized controlled trials reveals the emerging evidence for combining multidomain li…
Nutrition
Cochrane Review Finds Intermittent Fasting Shows Modest Weight Loss
A comprehensive Cochrane systematic review evaluated randomized controlled trials comparing intermittent fasting protoc…
Studies
Beta-Blocker Guidelines Face Challenge in Post-Heart Attack Recovery
Clinical evidence suggests current beta-blocker protocols following heart attacks may need refinement, particularly reg…
Studies
CTNS Gene Therapy Shows Promise for Inherited Kidney Disease
A novel gene therapy approach targeting CTNS mutations demonstrates therapeutic potential for nephropathic cystinosis,…
Studies
Immunotherapy Drug Achieves 9-Year Melanoma Survival Plateau
Nivolumab, a PD-1 checkpoint inhibitor, demonstrates remarkable durability in advanced melanoma patients with survival…
Studies
Alpibectir Revives Abandoned TB Drug Ethionamide Against Resistant Strains
Alpibectir demonstrates the ability to restore therapeutic efficacy to ethionamide, a tuberculosis drug largely abandon…
Studies
ALK2 Inhibitor Engasertib Reduces Nosebleeds in Rare Vascular Disease
Engasertib, a selective ALK2 kinase inhibitor, demonstrated significant reduction in epistaxis frequency among patients…
Studies
Modified Stem Cells Deliver Functional CTNS Gene in Cystinosis Trial
Researchers successfully used genetically modified hematopoietic stem cells to deliver functional CTNS genes in patient…
Studies
Targeted RNA Therapy Reduces Toxic Transcripts in Myotonic Dystrophy
An antibody-oligonucleotide conjugate demonstrated selective reduction of toxic RNA transcripts in myotonic dystrophy t…
Studies
Combination Immunotherapy Shows Promise for Bladder Cancer Surgery Patients
A dual-agent regimen combining the antibody-drug conjugate enfortumab vedotin with the PD-1 inhibitor pembrolizumab dem…
Studies
Dual Immunotherapy Combination Shows Promise for Bladder Cancer Surgery
Clinical trial data reveals that combining enfortumab vedotin with pembrolizumab before and after bladder cancer surger…
Studies
Long-Acting HIV Injections Show Promise for Adherence-Challenged Patients
Monthly or bimonthly injections of cabotegravir combined with rilpivirine demonstrated sustained viral suppression in H…
Studies
Research Framework Links Chronic Infections to Long-Term Disease Patterns
A new analytical framework proposes standardizing how researchers study the connections between infectious agents and c…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.