Supplements
Resveratrol Fights Obesity via p38-ATF3-GDF15 Brain Signaling Cascade
Resveratrol dose-dependently upregulates GDF15 mRNA, protein expression, and secretion in both murine embryonic…
Nutrition
Gut-Microbiota Diet Score Linked to 22% Lower MASLD Risk in 168K UK Biobank Adults
Among 168,456 UK Biobank participants followed prospectively, those scoring ≥6 on the Dietary Index for Gut Microbiota…
Nutrition
Gut Metabolite ImP Associated with 82% Higher CHD Risk in Cohorts; Pectin Intake May Modulate Levels
Plasma imidazole propionate (ImP)—a microbial metabolite of histidine produced via the urocanate reductase pathway—was…
Longevity
Ergothioneine Mediates 31.5% of Antacid-Linked Cognitive Decline Risk
Screening 991 blood metabolites against cognitive performance and brain MRI markers in 1,082 dementia-free middle-aged…
Longevity
Diabetes Alters 4 Gut Taxa in Elderly Nursing-Home Residents, Not Diversity
In 173 nursing-home residents averaging 86 years of age (77.5% female), diabetes mellitus — present in 51 participants…
Longevity
Gut Metabolite ImP Potentiates Tau Hyperphosphorylation via GSK-3β and Alzheimer's Pathology
In a 1,196-person cognitively unimpaired cohort, elevated plasma imidazole propionate (ImP) — a gut bacterial…
Longevity
45,454 Gut Microbiomes Link Medication-Associated Oral Bacteria to Aging-Disease Microbiome Overlap
A computational re-examination of 45,454 gut microbiomes across 141 studies identified 15 microbial taxa…
Longevity
16-Microbe Gut Signature Discriminates Frailty Across 28 Cohorts, 24 Countries
Across 955 individuals drawn from 28 independent cohorts spanning 24 countries, a metagenomic meta-analysis pinpointed…
Wellbeing
Psychedelic Therapy Efficacy Confirmed in Phase II-III Trials Across Six Compounds
For the millions of adults who have failed multiple antidepressants or remain trapped in PTSD cycles, the promise of…
Wellbeing
One-Third of Seasonal Allergy Patients Perceive Real-Time Pollen Data as Potentially Helpful for Symptom Management
For the roughly one in five adults dealing with seasonal hay fever, the gap between available treatments and actual…
Studies
ENO1-HDAC1 Coupling Regulates Histone Lactylation and Oncogene Transcription in Cancer Cells
Epigenetics rarely generates headlines outside specialist circles, yet this particular discovery touches something…
Wellbeing
Brain Connectivity Follows Unified Spatial-Temporal Rules Across All Timescales
How the brain maintains coherent function across milliseconds and minutes has puzzled neuroscientists for decades…
Studies
Competing Microbial Signals Create Antibiotic Tolerance Hotspots Inside Biofilms
Antibiotic treatment failures are not always about resistance genes — sometimes the problem is geography…
Studies
Fish-Specific Oxygen Sensor Activates Immunity Via Novel Non-Enzymatic Mechanism
Understanding how oxygen levels regulate immune responses could reshape how scientists approach inflammatory diseases…
Longevity
p53 Cell-Cycle Genes Gtse1 and Cdkn1a Are Critical Effectors in Mouse Model of Constitutive p53 Activation
Understanding what actually executes p53's tumor-suppressing and aging-related commands inside living organisms—not…
Fitness
MyoD1 Dosage Controls Muscle Gene Networks Far Beyond Known Binding Sites
How much of a transcription factor matters as much as whether it is present at all — a distinction that has quietly…
Longevity
Aging Silences Long Genes While Splicing Errors Reshape Cellular Identity
Every cell in the aging body carries a molecular archive quietly rewriting itself — and understanding exactly how that…
Studies
Wounding Triggers Local Sugar Conversion and Uptake to Fuel Plant Tissue Repair
Understanding how living organisms rapidly redirect metabolic resources to sites of injury has long been a central…
Studies
Complete Dystrophin Knockout Mouse Reveals True DMD Muscle Stem Cell Collapse
The accuracy of animal models determines whether therapies developed in the lab will ever help real patients — and for…
Studies
Gene Therapy Restoring ER-Mitochondria Crosstalk Reverses CMT2A Neuropathy Markers
For the roughly 1-in-2,500 people carrying inherited peripheral neuropathies, disease-modifying treatments have…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.