Studies
Brain-Penetrant Molecule Targets TDP-43 Core Region, Extends ALS Mouse Survival
For the roughly 30,000 Americans living with ALS at any given time, disease-modifying options remain desperately…
Longevity
NKG2A Checkpoint Blockade Clears Senescent Fibroblasts, Reverses Lung Fibrosis
For the millions living with idiopathic pulmonary fibrosis — a progressive, largely untreatable scarring disease with…
Fitness
Muscle Multiomics Reveals Which Aging Signatures Exercise Cannot Reverse
For decades, exercise has been championed as the closest thing to an anti-aging intervention available to healthy…
Supplements
Flavonoids, Alkaloids, and Terpenoids Show Multitarget Neuroprotection Across Four Major Neurodegenerative Diseases
For the roughly 50 million people worldwide living with Alzheimer's, Parkinson's, Huntington's disease, or ALS…
Studies
One-in-Four Lacunar Stroke Patients Deteriorate Early Despite Mild Onset Symptoms
For clinicians and patients alike, mild stroke symptoms can create a dangerous sense of reassurance — yet for a…
Studies
Lacunar Stroke's Hidden Instability: Why 1-in-4 Patients Worsen Early
For patients and clinicians who assume small strokes mean small consequences, a comprehensive review of subcortical…
PREPRINTLongevity
Liver Fibrosis Linked to 54% Higher AF Risk: Metabolomic Clock Reveals Dual Cardiac Pathways
Among 403,974 UK Biobank participants followed for 13+ years, high-risk liver fibrosis scores (NFS hazard ratio 1.54…
PREPRINTLongevity
PREVENT Equations Predict MACE in 278 HFpEF Patients Beyond NT-proBNP
Applied to 278 patients hospitalized for acutely decompensated HFpEF (median age 75, 51.4% male), the AHA's PREVENT…
PREPRINTStudies
Simulation Model Reveals Impella RP's Pulmonary Pressure Trade-Off in Failing Right Heart
Using the CARDIOSIM numerical simulation platform, researchers modeled two configurations of the Impella RP right…
PREPRINTLongevity
27.6% of Screened Relatives Test Positive for Aortic Disease in 1,022-Proband Cohort
Among 1,022 probands with thoracic aortopathy assessed at a Canadian cardiac clinic between 2009 and 2024, only 43.5%…
PREPRINTStudies
Dapagliflozin Cuts Venous Pressure 1.3 mmHg in Fontan Adults Over 4 Weeks
Four weeks of dapagliflozin 10mg daily reduced resting peripheral venous pressure by 1.3 mmHg (p=0.012) in 26 adult…
Longevity
Senescent Stem Cells Accelerate Disc Degeneration: MMP1/3/13 Upregulation Drives Failure
Young rabbit adipose-derived mesenchymal stem cells (rADSCs) demonstrated strong chondrogenic differentiation…
Longevity
Engineered Iron Oxide Nanoparticles Transfer Rejuvenated Mitochondria to Reverse Bone Aging
Engineered iron oxide nanoparticles—KGM-PEG-SPIONs, functionalized Fe3O4 particles—rescue aging bone marrow by solving…
Longevity
α-Ketoglutarate Reverses Stem Cell Senescence via LKB1-AMPK-Mitochondrial Axis
Alpha-ketoglutarate (α-KG), a TCA cycle intermediate, rescues human periodontal ligament stem cells (HPDLSCs) from…
Studies
In Silico Study Identifies Tinospora cordifolia Compounds 137706608 & 5281712 as Potential Smo Agonists for MS Remyelination Research
Two bioactive compounds from Tinospora cordifolia — PubChem IDs 137706608 and 5281712 — emerged as top candidates from…
Longevity
Alpha-Diversity Fails as Alzheimer's Biomarker; Microbial Composition Patterns Hold Promise
Pooling data from 23 observational studies (698 AD patients, 485 with mild cognitive impairment, 1,060 cognitively…
Studies
AGK Suppression Triggers Senescence and TMZ Resistance in Glioblastoma Cell Models; FOXO4-DRI Senolytic Restores Sensitivity
High acylglycerol kinase (AGK) expression in glioblastoma correlates with poor prognosis in TCGA patient data…
Nutrition
Traditional Chinese Formula Suppresses Asthma via Gut Microbiome-Tryptophan-ILC2 Pathway
For millions of asthma patients who respond inadequately to conventional therapies, understanding how the gut shapes…
Studies
Dual Mobility Hip Implants Show No Statistical Edge Over Standard Bearings
For the millions of adults undergoing total hip replacement each year, the choice of implant bearing can mean the…
Studies
Frozen Testicular Cells From Cancer Survivors Reprogrammed Into Viable Germ Cells
For the boys who survive childhood cancer, the victory often carries a hidden cost: permanent infertility caused by…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.