PREPRINTLongevity
Wrist Device Tracks Heart Failure Decongestion with 0.85 AUC Readmission Signal
A wrist-worn, machine-learning device analyzing venous waveforms — the NIVAHF device — produced a non-invasive…
Studies
Fluvoxamine Cuts Long COVID Fatigue Scores in 399-Patient Randomized Trial
For millions of adults still grappling with crushing fatigue months after a COVID-19 infection, the absence of proven…
Studies
Cancer Survivors and Oncology Providers Diverge Sharply on Cannabis Risk Awareness
When patients and their oncologists hold fundamentally different assumptions about the same therapy, clinical…
Studies
Itch-Sensing GPCR MRGPRX4 Identified as Potent Melanoma Driver and Therapy Target
Melanoma's notorious resistance to therapy often traces back to poorly understood dedifferentiation programs — the…
Studies
EBV Molecular Mimicry and Helminth Immunomodulation Reshape MS Pathogenesis Framework
Multiple sclerosis research has long grappled with a frustrating paradox: genetic risk explains only a fraction of who…
Nutrition
GLP-1 Agonists and Bariatric Surgery Cut Uric Acid, Reframe Gout Treatment
Excess adiposity causally elevates serum uric acid (SUA) through at least four converging mechanisms: insulin…
Longevity
Review Maps Microplastics-Gut Microbiome Links to Aging Pathways Including TLR4/NF-κB
Micro- and nanoplastics (MNPs) enter the human body through oral ingestion, inhalation, and dermal absorption, and…
Longevity
Manganese Overload Triggers Cellular Senescence via STING; Quercetin Reverses Damage
Excess manganese (Mn) — encountered occupationally in welding, mining, and battery manufacturing — drives cellular…
Nutrition
Time-Restricted Eating for Fatty Liver May Erode Muscle, Trigger Rebound Weight Gain
For the millions managing metabolic fatty liver disease, intermittent fasting and calorie restriction have emerged as…
Studies
XGBoost Model Uses Clinical Notes to Forecast Pediatric Asthma Attacks
Childhood asthma remains one of the most burdensome chronic conditions in pediatrics, yet clinicians still lack…
Studies
Central Harlem Legionnaires' Outbreak Traced to Two Cooling Towers via Genomic Sequencing
Urban water infrastructure remains one of the most underappreciated public health threats for city dwellers — and a…
PREPRINTStudies
PFA Stroke Risk 16x Higher for Varipulse vs. Near-Zero for Farapulse
A systematic analysis of 2,262 adverse event reports from the FDA's MAUDE database — 760 involving pulsed field…
PREPRINTLongevity
Higher Plasma Acetate Linked to Reduced Heart Risk in Early Menopause: Large Biobank Study
Across 105,563 females from UK Biobank and Biobank Japan followed up to 10 years, higher plasma acetate — the dominant…
PREPRINTLongevity
CYP11B2 C-allele Associated with 6-Fold Higher Hypertension Odds in Ghanaian Cohort
The CC genotype of the CYP11B2 rs1799998 (T-344C) promoter polymorphism carried a 6.35-fold greater odds of…
PREPRINTLongevity
Preliminary Analysis: GLS Cut-Off of -17% Shows 0.89 AUC for Identifying Reduced LVEF by CMR
A secondary diagnostic accuracy analysis of 34 patients found that a global longitudinal strain (GLS) cut-off of…
PREPRINTLongevity
Self-Supervised ECG AI Predicts Death Risk Across 6 Independent Cohorts
A self-supervised transformer model trained on over 7.2 million ECGs quantifies how difficult it is to reconstruct a…
Longevity
Italy's 16-Year Healthspan Gap Demands Systemic Longevity Medicine Overhaul
Italy's demographic profile is stark: 24.1% of its population is aged ≥65 — the EU's highest — yet healthy life years…
Studies
Second-Trimester Air Pollution Exposure Linked to 48–64% Higher Odds of Low Apgar Score
Newborn vitality at birth is a compressed snapshot of everything that happened in the womb — and mounting evidence…
Studies
LIG1 Loss Marks TNBC Tumors Vulnerable to Olaparib-Ceralasertib Combination
Triple-negative breast cancer remains among the most treatment-resistant malignancies precisely because it lacks the…
Wellbeing
Hypoglossal Nerve Stimulation Linked to Lower Cardiovascular Risk in Sleep Apnea
For the roughly 30 million Americans with obstructive sleep apnea who cannot tolerate CPAP, the cardiovascular…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.