Studies
Sildenafil Traps Lysosomal Cholesterol, Curbing Metastasis via NPC1 Pathway
The possibility that a widely prescribed erectile dysfunction drug could meaningfully interfere with cancer spread…
Studies
Dynamic Biomarker Trajectories Sharpen Progression Risk Prediction in Pre-Myeloma
For the roughly 15,000 Americans diagnosed annually with smoldering multiple myeloma, the central clinical dilemma is…
Studies
African American Brain Networks Show ABCA7 Risk Exceeds APOE-ε4 Impact
Alzheimer's disease research has long centered on APOE-ε4 as the dominant genetic risk factor, yet that lens was…
Studies
Global TB Deaths Declined Substantially Since 1990, But MDR-TB Threatens Hard-Won Gains
Tuberculosis remains one of the most consequential infectious diseases in human history, and for the first time in…
Studies
GLP-1 Drugs Reshape Plastic Surgery Research: 3 Emerging Domains Identified
A bibliometric sweep of the 50 most-cited publications on GLP-1 receptor agonists (GLP-1 RAs) intersecting plastic and…
Longevity
Exercise + Ginsenosides Suppress BACE1 but Combined Therapy Underperforms Alone
In middle-aged Wistar rats (n=30), aerobic exercise and ginsenoside supplementation each independently suppressed…
Longevity
Senescent Theca Cells Linked to Ovarian Aging via CCL5, TNF-α, GSK3β Pathway in Preclinical Studies
Ovarian aging research has long centered on oocyte quality and granulosa cell decline, but a comprehensive…
Studies
Intraoperative Imaging and AR Navigation Redefine Safe Glioma Resection Boundaries
For the roughly 25,000 Americans diagnosed annually with malignant brain gliomas, how much tumor a surgeon can safely…
Studies
Triple Hormone Agonist Retatrutide Cuts HbA1c and Weight in Phase 3 Trial
For the millions of adults managing early type 2 diabetes through diet and exercise alone, the therapeutic window…
Studies
Global TB Burden Mapped Across 204 Nations: MDR-TB and HIV Progress Assessed
Tuberculosis remains one of the most consequential infectious disease burdens on the planet, yet its trajectory — and…
Studies
Antibodies Targeting TβRI Cleavage Inhibit Androgen-Independent Prostate Cancer Growth and Metastasis in Preclinical Models
For men whose prostate cancer has outrun hormone therapy, treatment options narrow sharply and survival odds remain…
Studies
Follistatin-IGF1R Signaling Axis Identified as Driver of Chronic Facial Pain
Trigeminal neuropathic pain — the severe, often treatment-resistant facial pain affecting millions worldwide — has…
Supplements
Spermidine Reverses B-Cell Senescence, Rescues COVID Vaccine Response in Elderly Non-Responders
Vaccine failure in older adults is not random — it may be biologically predictable and, critically, potentially…
Studies
Synthetic Cannabinoids Block Key Cardiac Ion Channel Linked to Fatal Arrhythmia
The rising global use of synthetic cannabinoids — marketed as legal alternatives to cannabis — has been accompanied by…
Longevity
PINK1-Phosphorylated Ubiquitin Emerges as Central Signal in Mitochondrial Disease Pathways
Understanding why neurons and heart cells die prematurely in neurodegenerative and cardiometabolic diseases may hinge…
Studies
iPSC Neural Stem Cell Transplant Clears Phase 1 Safety Bar in Spinal Cord Injury
For the millions living with paralysis from spinal cord injury — a condition medicine has long considered largely…
Studies
Personalized Gene-Silencing Therapy Cuts Seizures in SCN2A Epilepsy Patients
For families living with treatment-resistant childhood epilepsy, the prospect of a therapy designed specifically…
Studies
Qdenga Dengue Vaccine Triggers Tetravalent Response in Only 8% of Naïve Adults
For a vaccine marketed as tetravalent protection against all four dengue serotypes, the actual breadth of immune…
Wellbeing
Accountability-Embracing Science Communication Rebuilds Conservative Trust Post-Pandemic
How scientists talk about their own mistakes may matter as much as the science itself — particularly for audiences who…
Studies
Pre-existing Anti-Interferon Autoantibodies Linked to Life-Threatening COVID-19 Severity
Understanding why a subset of otherwise healthy individuals develops catastrophic viral pneumonia while others recover…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.