Analysis of 18,798 participants across 33 studies reveals high-risk human papillomavirus affects 28.95% of sexually active individuals in Cameroon, with striking variation by population. Women with precancerous lesions showed 90.69% prevalence while general population rates were 21.09%. The data suggests encouraging progress, with prevalence declining from 53.34% before 2014 to 21.43% in 2021-2023. Among HPV-positive women, HIV co-infection reached 26.17%, highlighting critical syndemic patterns. This comprehensive national synthesis fills important epidemiological gaps for a region where cervical cancer ranks among leading causes of female cancer mortality. The findings support targeted prevention strategies, particularly for high-risk populations like sex workers and HIV-positive women. However, the extremely high heterogeneity between studies (I² = 98.7%) suggests significant methodological variations that may limit interpretation. As a preprint awaiting peer review, these prevalence estimates require validation before informing policy. The temporal decline offers cautious optimism but demands continued surveillance to confirm sustainability and understand underlying drivers of this apparent improvement.