Meta-analysis of 5,876 colorectal cancer patients reveals Enhanced Recovery After Surgery (ERAS) protocols significantly improve survival rates across multiple timeframes. One-year survival increased from 90.2% to 93.2%, while five-year survival jumped from 60.6% to 70.9%. The protocol reduced long-term mortality risk by 28%, with early-stage tumors and adherence rates above 70% showing the greatest benefits. ERAS represents a comprehensive perioperative approach combining nutritional optimization, early mobilization, pain management, and surgical technique refinements. This finding extends ERAS benefits beyond well-established short-term outcomes like reduced hospital stays and complications. The survival advantage likely stems from reduced surgical stress, better immune function preservation, and faster physiological recovery that may limit cancer recurrence opportunities. However, disease-free survival showed no significant improvement, suggesting ERAS primarily enhances overall health resilience rather than directly preventing cancer spread. The moderate study quality and observational nature limit causal conclusions. As this preprint awaits peer review, results may change, but the consistency across multiple timeframes and large patient cohort suggests ERAS could become standard colorectal cancer care, potentially saving thousands of lives annually through systematic perioperative optimization.