Among 14 consensus aging biomarkers tested in 1,083 German adults aged 60-80 over 7.4 years, the DunedinPACE epigenetic clock demonstrated the strongest association with all-cause mortality, outperforming traditional markers like inflammatory cytokines, muscle strength, and cognitive measures. Only five biomarkers—DunedinPACE, hand grip strength, IL-6, standing balance, and cognitive health—significantly predicted mortality in adjusted models. This finding marks a significant shift in aging research methodology. While biological age clocks have gained attention, most studies have compared just a few markers or focused on specific populations. This comprehensive head-to-head comparison across physiological, inflammatory, functional, and epigenetic domains provides the most robust evidence yet for DunedinPACE's superiority. The practical implications are substantial: rather than expensive panels of multiple biomarkers, clinicians and researchers might focus on epigenetic testing combined with simple physical assessments. However, the study's European ancestry population and relatively short follow-up period limit generalizability. The finding that a minimal three-biomarker set achieved nearly identical predictive accuracy (C-index 0.63 vs 0.65) suggests diminishing returns from complex biomarker panels—a paradigm-shifting insight for precision aging medicine.