Forty-six older adults with sarcopenia completed a 12-week home-based virtual reality aerobic exercise program combined with resistance training three times weekly. The VR group demonstrated significant improvements across all sarcopenia markers: skeletal muscle mass index increased, handgrip strength improved substantially (effect size 0.599), gait speed enhanced, and depression scores decreased markedly. Control participants receiving only self-care education experienced declining muscle mass and strength over the same period. This controlled trial addresses a critical intersection in aging research where sarcopenia and depression often co-occur and amplify each other's detrimental effects. The home-based VR approach solves multiple barriers facing older adults: accessibility, engagement, and concurrent treatment of physical and psychological decline. While the sample size remains modest at 46 participants, the effect sizes are robust and the intervention's dual benefit on muscle health and mood represents a meaningful advance. The non-immersive VR format makes this intervention scalable and practical for widespread adoption. This finding could reshape how we approach sarcopenia prevention, moving beyond traditional exercise prescriptions to technology-enhanced interventions that simultaneously combat the physical frailty-depression cycle that accelerates aging.