Analysis of 24 studies spanning multiple databases reveals COVID-19 produces a uniquely broad and severe pattern of neurological injury compared to influenza, dengue, and other viral infections. The SARS-CoV-2 virus triggers central nervous system complications including stroke, encephalitis, seizures, and extensive white matter damage, alongside peripheral manifestations like persistent smell loss, Guillain-Barré syndrome, and chronic nerve conduction abnormalities. This comprehensive neurological profile distinguishes COVID-19 from typical viral patterns. The finding helps explain why many COVID patients experience prolonged cognitive symptoms and neurological deficits that persist well beyond acute infection. For clinicians, this systematic comparison provides crucial context for diagnosing and managing post-viral neurological complications, suggesting COVID patients may require more intensive and prolonged neurological monitoring than those recovering from seasonal flu or other common viral illnesses. The research also indicates that COVID's neurological impact may contribute significantly to long-term disability burden, particularly given the virus's global reach. However, the heterogeneity in study designs limits definitive conclusions about mechanisms, and more standardized comparative studies are needed to fully quantify COVID's unique neurological signature.