A systematic review of 24 studies reveals SARS-CoV-2 produces the most extensive neurological damage spectrum among common viral pathogens. The analysis documents central nervous system effects including stroke, encephalopathy, seizures, and distinctive microglial activation with white matter injury in fatal cases, alongside peripheral manifestations like anosmia, Guillain-Barré syndrome, and persistent nerve conduction abnormalities months post-recovery. This comprehensive neurological profile distinguishes COVID-19 from influenza and other respiratory viruses, which typically cause more limited and transient nervous system involvement. The findings have significant implications for post-acute care planning, as the persistent peripheral neuropathies and cognitive effects suggest COVID-19 may require longer rehabilitation periods than previously assumed. The review's strength lies in comparing multiple viral pathogens using consistent methodology, though the authors acknowledge heterogeneous study designs limit precise quantitative comparisons. For clinicians managing long COVID patients, this evidence supports more aggressive neurological screening and earlier intervention for cognitive and peripheral nerve symptoms. The data also suggests healthcare systems should prepare for sustained neurological rehabilitation needs, as COVID-19's neurotropic effects appear more severe and durable than typical post-viral syndromes.