Researchers interviewed 31 individuals with obesity and 18 healthcare professionals to develop a comprehensive model of 'obesogenic memory' that extends beyond known molecular mechanisms. While previous research established that obesity creates lasting epigenetic changes in fat tissue that promote weight regain after loss, this qualitative study proposes that sociocultural factors also create persistent 'memories' that maintain obesity over time. The three-phase model encompasses memorizing (initial biological and social encoding), remembering (persistence of obesogenic influences), and rescribing (potential reversal processes). This framework represents a significant conceptual advance by acknowledging that obesity persistence involves complex interactions between molecular reprogramming and lived social experiences. For adults struggling with weight management, this suggests that effective interventions must address both biological predispositions and sociocultural environments that reinforce obesogenic behaviors. However, as a qualitative study with modest sample sizes, the model requires validation through larger quantitative research. Additionally, this preprint has not undergone peer review, so the proposed framework may evolve. The integration of biological and social dimensions could reshape obesity treatment approaches from purely medical interventions toward more holistic, multilevel strategies.
Obesogenic Memory Model Integrates Biological and Social Obesity Persistence Factors
📄 Based on research published in medRxiv preprint
Read the original research →⚠️ This is a preprint — it has not yet been peer-reviewed. Results should be interpreted with caution and may change following peer review.
For informational, non-clinical use. Synthesized analysis of published research — may contain errors. Not medical advice. Consult original sources and your physician.