A randomized controlled trial involving 58 patients demonstrated that minor papillotomy—a minimally invasive endoscopic procedure—reduced recurrent pancreatitis episodes by approximately 70% in individuals with pancreas divisum, a congenital anatomical variant affecting 5-10% of the population. The intervention involves creating a small incision in the minor papilla to improve pancreatic drainage in cases where normal ductal anatomy is disrupted. This finding addresses a longstanding clinical dilemma in gastroenterology. Pancreas divisum has been suspected as a contributing factor to recurrent pancreatitis for decades, but definitive evidence for therapeutic intervention has remained elusive. The condition involves incomplete fusion of pancreatic ducts during embryonic development, potentially creating drainage bottlenecks that trigger inflammatory episodes. This trial provides the first Level 1 evidence that mechanical correction of the drainage pathway can meaningfully reduce disease recurrence. The intervention appears most relevant for younger patients experiencing unexplained recurrent pancreatitis, where other common causes like gallstones or alcohol have been ruled out. However, the small sample size and single-center design warrant cautious interpretation until larger multicenter trials confirm these promising results across diverse patient populations.