Literary analysis of physician-poet William Carlos Williams and contemporary depression poetry demonstrates how poetic expression transforms clinical medical experiences into accessible emotional landscapes. Williams, who practiced general medicine serving low-income immigrants, used plainspoken language to elevate illness as worthy of artistic attention, particularly in works addressing anhedonia, bereavement, and isolation. This approach to medical humanities offers compelling insights for modern therapeutic communication. The intersection of clinical practice and creative expression suggests untapped potential for healthcare providers to better understand patient experiences through literary frameworks. Poetry's capacity to articulate suffering without sentimentality may enhance empathetic care delivery, particularly in mental health contexts where traditional clinical language often falls short. The analysis reveals how artistic interpretation of medical conditions can bridge the gap between clinical observation and human experience, offering healthcare professionals alternative vocabularies for discussing complex emotional states. While this represents literary criticism rather than clinical research, the exploration points toward poetry therapy's documented benefits and suggests that medical education might benefit from incorporating humanistic perspectives. The work underscores how creative expression can illuminate aspects of illness that purely clinical descriptions miss, potentially improving both patient communication and provider understanding of subjective disease experiences.