Live imaging of tumor blood vessels reveals that engineered Salmonella strain YB1 gets physically trapped in the chaotic architecture of cancer vasculature, particularly in irregular structures researchers termed "shoulder" and "maze" formations. This mechanical entrapment allows direct bacterial contact with endothelial cells, causing vessel damage and triggering blood clots that starve tumors of oxygen. The bacterial approach represents a departure from conventional cancer therapies that target tumor cells directly. Instead, YB1 exploits the disorganized vascular networks that distinguish cancerous tissue from healthy organs, essentially weaponizing the tumor's own blood supply against itself. The hypoxic environment created by vascular blockade paradoxically enhances bacterial colonization, as Salmonella thrives in low-oxygen conditions. This creates a self-reinforcing cycle where initial bacterial entrapment leads to conditions that support further bacterial growth. However, the study used immunocompromised mice, raising questions about how intact immune systems might clear the bacteria before therapeutic effects occur. The vascular targeting mechanism could prove especially valuable for solid tumors that resist conventional treatments due to poor drug penetration, though clinical translation requires careful safety evaluation given the pathogenic potential of Salmonella.