Danish registry data spanning three decades reveals that maternal bacterial, viral, and other infections during pregnancy correlate with a 57% higher suicide attempt rate in offspring (141.2 vs 90.0 per 100,000 person-years). The analysis encompassed 2.16 million individuals tracked from age 10 upward, with nearly 39,000 exposed to maternal infections during gestation and 32,275 who later attempted suicide. This finding adds crucial evidence to the fetal programming hypothesis, which proposes that prenatal immune activation can permanently alter neurodevelopmental trajectories. Previous research has linked maternal infections to increased risk of schizophrenia, autism, and mood disorders in offspring, but this represents the first large-scale examination of suicide risk specifically. The mechanism likely involves inflammatory cytokines crossing the placental barrier during critical brain development windows, potentially disrupting serotonergic and dopaminergic systems that regulate mood and impulse control. While the observational design cannot establish causation, the researchers' inclusion of paternal infection data helps control for genetic and socioeconomic confounders. For expecting mothers, this underscores the importance of infection prevention and prompt treatment, though the absolute risk remains relatively low. The findings may eventually inform targeted mental health screening protocols for children with documented prenatal infection exposure.