Comparative evolutionary research is revealing new pathways for potentially extending reproductive lifespan in humans. By examining species with drastically different reproductive patterns—from mice that experience menopause-like states within months to whales that maintain fertility for decades—scientists are identifying molecular mechanisms that could influence ovarian aging. This cross-species approach represents a fundamental shift from traditional hormone replacement therapy toward interventions that might delay menopause itself rather than merely treating its symptoms. The research builds on emerging evidence that reproductive aging is not a fixed biological clock but a malleable process influenced by cellular repair mechanisms, metabolic factors, and stress response pathways. Early intervention strategies targeting these evolutionary-conserved mechanisms could theoretically extend healthspan by maintaining hormonal balance longer. However, translating insights from long-lived marine mammals or laboratory models to human therapeutics faces significant challenges, including species-specific genetic differences and the complex interplay between reproductive hormones and age-related diseases. The most promising near-term applications may focus on biomarkers that predict individual variation in menopause timing, enabling personalized approaches to reproductive health planning rather than population-wide interventions.