Extending overnight fasting by finishing meals at least three hours before bedtime significantly enhanced nighttime diastolic blood pressure dipping and autonomic nervous system function in overweight adults aged 36-75. The 7.5-week randomized trial compared participants following 13-16 hour fasts aligned with sleep schedules against controls maintaining typical 11-13 hour eating patterns. While insulin sensitivity showed no improvement, morning glucose tolerance and nighttime cardiovascular recovery both benefited from the sleep-synchronized approach. This finding challenges the prevailing focus on total fasting duration in time-restricted eating protocols. The circadian alignment appears more critical than previously recognized, as the body's natural overnight repair processes seem optimized when digestion concludes well before sleep onset. Unlike rigid intermittent fasting schedules that often conflict with social eating patterns, this individualized approach works within existing sleep habits while targeting the metabolically active overnight period. The modest three-hour extension represents a potentially sustainable modification for cardiovascular health, particularly relevant given that nighttime blood pressure regulation strongly predicts long-term cardiac outcomes. However, the study's relatively short duration and focus on overweight participants limits broader applicability until longer-term trials confirm whether these acute improvements translate to sustained cardiometabolic benefits across diverse populations.