Virtual screening reveals 4,4'-diapophytofluene (4,4'-DPE), extracted from coconut leaves, demonstrates stronger binding affinity to five critical aging-regulatory proteins—SIRT-1, Bcl-xL, Hsp-90, MDM-2, and mTOR—compared to established anti-aging compounds quercetin, curcumin, resveratrol, and fisetin. Molecular dynamics simulations over 100 nanoseconds confirmed thermodynamically stable interactions with minimal structural deviations. This computational discovery builds meaningfully on emerging senotherapeutic research, where compounds that selectively eliminate or modulate senescent cells represent a frontier in longevity interventions. The superior binding profiles suggest 4,4'-DPE could potentially influence cellular aging pathways more effectively than current botanical standbys. However, this remains purely theoretical—computational binding affinity doesn't guarantee biological efficacy or bioavailability in living systems. The gap between molecular docking success and clinical outcomes is substantial, requiring extensive cell culture, animal studies, and human trials. While intriguing as a lead compound for drug development, translating these promising virtual results into actual anti-aging benefits faces significant hurdles. The research represents solid computational groundwork rather than actionable health guidance.