A large-scale field trial in Indonesia demonstrates that releasing male Aedes aegypti mosquitoes infected with Wolbachia bacteria achieved a 77% reduction in dengue incidence across treated areas. The bacterial symbiont disrupts viral replication within mosquito hosts while rendering offspring non-viable when Wolbachia-infected males mate with wild females, creating population suppression effects that persist for months after releases cease. This biological control approach represents a significant advancement over previous Wolbachia strategies that relied on population replacement rather than suppression. The magnitude of dengue reduction rivals that achieved by traditional vector control methods but without pesticide resistance concerns or environmental toxicity. The technique shows particular promise for urban tropical regions where Aedes aegypti thrives in small breeding sites difficult to eliminate through conventional approaches. However, implementation requires sophisticated laboratory infrastructure for mosquito rearing and quality control, potentially limiting scalability in resource-constrained settings. The durability of suppression effects and optimal release frequencies remain important questions for operational deployment. If reproducible across diverse ecological contexts, this sterile insect technique could transform dengue prevention strategies for the 390 million people infected annually worldwide.