Analysis of cardiovascular event data reveals chronic stress serves as a primary biological mediator connecting depression and anxiety disorders to major cardiac episodes. The research identifies specific stress-response pathways that translate psychological distress into measurable cardiovascular risk, offering mechanistic insight into a relationship long observed epidemiologically. This finding represents a significant advance in psychocardiology, moving beyond correlation to demonstrate plausible causative mechanisms. The stress-mediation model suggests that interventions targeting chronic stress responses could potentially interrupt the pathway from mental health disorders to heart disease. This has profound implications for integrated care approaches, particularly for the estimated 40 million American adults with anxiety disorders who may unknowingly face elevated cardiac risk. The research validates decades of clinical observation while opening new therapeutic avenues. However, the complexity of stress biology means that effective interventions will likely require personalized approaches rather than one-size-fits-all solutions. The findings also highlight the inadequacy of treating mental health and cardiovascular health in isolation, suggesting that optimal patient outcomes may require coordinated care models that address both psychological and physiological stress responses simultaneously.