Analysis of 12,906 Chinese adults revealed that accumulating multiple age-related functional impairments creates a more powerful mortality predictor than any single deficit. The study tracked visual, hearing, cognitive, and physical limitations, finding that individuals with three or more concurrent impairments faced substantially elevated death risk compared to those with isolated problems. This validates the biological concept that aging represents systemic damage accumulation rather than organ-specific decline. The finding supports a shift toward comprehensive functional assessment in clinical practice, moving beyond traditional single-biomarker approaches to mortality prediction. While the correlation between multiple deficits and death risk seems intuitive, quantifying this relationship provides crucial data for personalized health interventions. The research suggests that preserving multiple functional domains simultaneously may be more protective than optimizing individual systems. However, the observational design cannot establish whether preventing one impairment reduces others, and the study's focus on Chinese populations may limit generalizability. For longevity-focused individuals, this reinforces the value of holistic health strategies that address cognitive, sensory, and physical function concurrently rather than prioritizing single interventions.