The article proposes a framework called PRIMARY-AI to establish outcomes-based standards for the safe and effective integration of artificial intelligence (AI) in primary care. It highlights the need to address potential risks and ensure patient-centered care as AI becomes more prevalent in this setting. The framework aims to guide the development, deployment, and monitoring of AI systems in primary care, focusing on key outcomes such as patient safety, clinical effectiveness, and equitable access. The authors emphasize the importance of ongoing evaluation and adaptation to address evolving challenges and maintain the integrity of primary care in the AI era.