The article profiles the influential work of a leading researcher in the field of geroscience, the study of the biological mechanisms underlying aging and age-related diseases. It highlights their pioneering contributions to understanding the "architecture of frailty" and their efforts to translate these scientific insights into practical interventions to promote healthy aging. The article suggests this researcher has played a pivotal role in advancing the field of translational geroscience, bridging the gap between fundamental aging research and the development of clinical applications.