March of Dimes data reveals US preterm birth rates have increased to 10.5%, representing a concerning upward trajectory that places American infants at heightened risk for developmental complications, respiratory disorders, and long-term cognitive challenges. The organization's annual assessment assigns the nation a D+ grade, reflecting suboptimal maternal and infant health outcomes compared to other developed countries. This trend reverses previous decades of gradual improvement and signals systemic healthcare delivery gaps. Rising preterm births correlate strongly with increased healthcare costs, extended NICU stays, and elevated risk of childhood disabilities including cerebral palsy and learning disorders. The data underscores persistent racial and socioeconomic health disparities, with Black women experiencing disproportionately higher preterm birth rates. From a population health perspective, this represents both immediate clinical challenges and long-term public health consequences, as preterm birth survivors often require specialized educational support and ongoing medical management. The findings highlight critical gaps in prenatal care access, maternal stress management, and preventive interventions that could potentially reduce these rates through evidence-based protocols.