A cross-sectional analysis of 1,106 Ghanaian adults revealed that 21.3% exhibited multidomain hypertension-mediated organ damage (HMOD) across cardiovascular, renal, and vascular systems. The prevalence surged dramatically with age: just 8.6% in adults under 45, climbing to 20.6% in middle age, and reaching 44.4% in those 60 and older. Researchers used brachial-ankle pulse wave velocity ≥14 m/s as a substitute for the gold-standard carotid-femoral measurement. This comprehensive African data fills a critical gap in global hypertension research, where sub-Saharan populations have been underrepresented despite bearing disproportionate cardiovascular disease burden. The age-stratified findings underscore how cumulative blood pressure exposure accelerates multisystem damage, potentially informing prevention strategies for aging populations in resource-limited settings. However, the cross-sectional design cannot establish causality, and device limitations required methodological substitutions that may affect international comparability. As a preprint awaiting peer review, these prevalence estimates require validation before informing clinical guidelines. The research represents important foundational work for understanding hypertension's multisystem impact in African populations, where cardiovascular disease increasingly drives mortality.