ADAPT-232, a standardized blend of adaptogenic herbs, significantly extended lifespan in C. elegans while enhancing thermal and oxidative stress resistance. Under glucose-induced metabolic stress, the formula restored mitochondrial integrity and reduced lipid accumulation by upregulating pink-1, dct-1, and lgg-2 genes, indicating enhanced mitophagy—the cellular process that removes damaged mitochondria. The compound also activated DAF-16 and NHR-49 signaling pathways, improving lipid metabolism and stress response. This research illuminates a crucial mechanism behind adaptogenic herbs' longevity benefits: orchestrated cellular housekeeping rather than simple antioxidant effects. The mitophagy activation is particularly significant because defective mitochondrial recycling underlies many age-related diseases, from neurodegeneration to cardiovascular dysfunction. While C. elegans studies don't always translate to humans, the conserved nature of mitochondrial biology suggests promise. ADAPT-232's ability to coordinate multiple protective pathways simultaneously—mitochondrial cleanup, lipid metabolism, and stress response—represents a more sophisticated therapeutic approach than single-target interventions. However, human studies are essential to validate these mechanisms and establish optimal dosing protocols for cardiovascular protection.