A case-control study of 50 colorectal cancer patients and 100 controls in Nouakchott, Mauritania found high salty food consumption associated with a striking 47-fold increased cancer risk (adjusted OR = 47.45). Low educational attainment also emerged as an independent risk factor with a 5-fold increase in odds. The study represents rare cancer epidemiology research from West Africa, a region undergoing nutritional transition as traditional diets shift toward processed foods. The astronomical salt association, while statistically significant, comes with an extremely wide confidence interval (4.83-466.40), suggesting substantial uncertainty around the precise magnitude of risk. The small sample size of just 50 cases severely limits statistical power and generalizability. Additionally, this preprint awaits peer review, meaning results could change following expert scrutiny. While the salt finding aligns with established mechanistic evidence linking high sodium intake to gastrointestinal inflammation and cancer promotion, the extreme effect size raises questions about potential confounding or methodological issues. The educational gradient likely reflects broader socioeconomic disparities in diet quality and healthcare access. These preliminary findings underscore the urgent need for larger, more rigorous studies to guide public health interventions in rapidly changing African food environments.