Soluble TNF receptor levels demonstrated strong correlations with VACS 2.0 frailty scores in a cohort of 30 veterans over 65 years old. The study also found that frailty scores correlated with the number of prescribed medications, suggesting a relationship between polypharmacy and functional decline. This finding adds to mounting evidence that chronic inflammation drives age-related frailty, potentially through tumor necrosis factor pathways that accelerate cellular dysfunction and muscle wasting. TNF receptors, when shed into circulation, may serve as accessible biomarkers for identifying frailty risk before clinical symptoms emerge. The connection between inflammation and frailty represents a promising therapeutic target, as anti-inflammatory interventions could theoretically slow functional decline in aging populations. However, this preprint study awaits peer review and has significant limitations including its small sample size and cross-sectional design, which prevents establishing causation. The veteran population may also limit generalizability to broader aging demographics. While the inflammatory-frailty link is well-established, determining whether soluble TNF receptors mechanistically contribute to frailty or simply reflect underlying pathology requires larger longitudinal studies with diverse populations.