Adults living in the most socially vulnerable neighborhoods scored 5.3 points lower on the Life's Essential 8 cardiovascular health scale compared to those in the least vulnerable areas, based on analysis of 3,168 participants from the CARDIA study tracked over 15 years. The most disadvantaged quartile showed particularly poor scores for nicotine exposure and physical activity, with deficits of 13 points in each domain. Socioeconomic status and household characteristics emerged as the primary drivers of these health disparities. This finding adds crucial context to growing evidence that zip code may be as important as genetic code for cardiovascular outcomes. The research suggests community-level interventions targeting neighborhood socioeconomic factors could yield substantial population health benefits, potentially closing cardiovascular health gaps that contribute to premature mortality. However, the study's observational design limits causal inference, and residential mobility patterns weren't strongly linked to health changes, suggesting other mechanisms may be at play. As a preprint awaiting peer review, these findings require validation before informing policy decisions, though they align with established research on social determinants of health.