Researchers developed a comprehensive framework to prioritize future cancer research by analyzing over 1,000 studies covering 151 dietary and lifestyle exposures across 28 cancer types. The system assigned priority scores based on study quantity, statistical significance, and novelty, with anthropometric measures like BMI (score 163) and height (score 40-163) ranking highest, followed by physical activity (100), sedentary behavior (64), and vitamin D (91). The analysis revealed that non-significant associations from the 2018 World Cancer Research Fund report—including folate-colorectal cancer, waist circumference-lung cancer, and tea-ovarian cancer links—are most likely to become statistically significant with additional evidence. This methodological framework addresses a critical gap in cancer prevention research by systematically identifying where future systematic reviews would yield the greatest scientific impact. The approach could accelerate discovery of actionable cancer prevention strategies by directing limited research resources toward the most promising areas. However, as an unpeer-reviewed preprint, these prioritization rankings may change following formal review. The framework represents an incremental but valuable contribution to research methodology, potentially streamlining how major health organizations update their evidence-based recommendations for cancer prevention through diet and lifestyle modifications.