Analysis of two large randomized trials involving college students found that multicomponent lifestyle interventions improved fruit and vegetable intake, reduced processed meat consumption, and extended sleep duration compared to controls. However, effectiveness varied significantly by demographic factors. Non-Hispanic participants showed greater dietary improvements, while Hispanic males exhibited higher body weight and waist circumference despite intervention, suggesting the programs were least effective for this subgroup. Black participants reported higher processed meat intake than White participants even within intervention groups. These findings highlight a critical gap in obesity prevention research, where one-size-fits-all approaches may inadvertently widen health disparities rather than reduce them. The differential responses suggest that metabolic, cultural, or socioeconomic factors may influence intervention uptake and effectiveness. For practical application, this indicates that college health programs need demographic-specific modifications rather than uniform protocols. The research underscores the importance of culturally tailored interventions, particularly for Hispanic males who appear most resistant to standard approaches. However, as this preprint awaits peer review, these demographic patterns require confirmation through rigorous evaluation before informing policy changes in campus wellness programs.