vCATCH technology achieves single-cell resolution mapping of covalent drug binding sites across intact mammalian tissues, offering unprecedented visualization of how therapeutic compounds distribute and engage their targets throughout living systems. The volumetric approach captures molecular interactions that traditional tissue sectioning methods miss, particularly in complex three-dimensional organ structures. This represents a significant methodological advance for pharmaceutical development, potentially accelerating drug discovery timelines by providing comprehensive target engagement profiles before clinical trials begin. The technique could fundamentally reshape how researchers evaluate drug selectivity and off-target effects, addressing a major bottleneck in translating promising compounds from laboratory to clinic. For cancer therapeutics specifically, understanding whole-body distribution patterns could optimize dosing strategies and predict resistance mechanisms. However, the technology's computational demands and requirement for specialized imaging equipment may limit immediate widespread adoption. The ability to visualize drug-target interactions across entire organisms marks a paradigm shift from reductionist approaches toward systems-level pharmaceutical analysis, though validation in human-relevant models remains necessary.