Analysis of 480 suspected cases in Venezuela's western plains revealed Guanarito virus (GTOV) infected 72 individuals with a striking 36.1% case fatality rate. The zoonotic hemorrhagic fever predominantly affected older agricultural workers aged 46-90, peaking during September-January seasons. Confirmed infections showed distinct clinical signatures including headache, hemorrhage, sore throat, and gastrointestinal symptoms that differentiated GTOV from common arboviruses like dengue and Zika. This epidemiological profile provides crucial insight into an understudied but deadly pathogen that has persisted in Venezuela's agricultural regions for decades. The high mortality rate and occupational clustering suggest significant public health implications for rural communities with limited healthcare access. The seasonal pattern aligns with agricultural cycles, potentially linking transmission to rodent reservoir dynamics during harvest periods. However, this preprint analysis awaits peer review, and the relatively small confirmed case sample of 72 patients limits broader epidemiological conclusions. The findings underscore the urgent need for improved surveillance and diagnostic capabilities in endemic regions, particularly given the virus's ability to cause severe hemorrhagic disease with mortality rates exceeding many well-known viral hemorrhagic fevers.