The ability to reach 100 years while maintaining relatively good health represents one of biology's most intriguing phenomena, yet the metabolic signatures that distinguish these exceptional individuals remain largely unexplored. Understanding these biochemical fingerprints could reveal targetable pathways for extending healthspan in the broader population. Analysis of over 1,400 metabolites in 213 participants from the New England Centenarian Study reveals that individuals who achieve extreme longevity possess distinctly elevated levels of primary and secondary bile acids, particularly chenodeoxycholic acid and lithocholic acid, compared to their offspring and age-matched controls. These centenarians also showed reduced levels of biliverdin and bilirubin, compounds typically associated with antioxidant activity, while maintaining stable steroid hormone levels. Critically, both elevated bile acids and steroids correlated with reduced mortality risk across the cohort. The research identifies several metabolic ratios that appear central to the aging process: tryptophan to kynurenine ratios linked to NAD+ production, ergothioneine to trimethylamine N-oxide ratios reflecting gut bacterial metabolism, and methionine to methionine sulfoxide ratios indicating oxidative stress management. From a longevity research perspective, this work represents a significant advance in metabolomic profiling of extreme aging. The bile acid findings are particularly noteworthy given these compounds' emerging roles in metabolic regulation and gut-liver axis communication. However, the observational nature limits causal inference, and the predominantly European ancestry cohort may not capture universal longevity metabolomics. The development of a metabolomic biological age clock adds practical value, potentially offering more nuanced aging assessment than chronological age alone. This foundational work sets the stage for interventional studies targeting bile acid metabolism and related pathways.